In order to avoid security-related warning messages when switching to secured connection, you may want either to:
- confirm the exception on the next page, or
- import our CA key in your web browser
Click here to proceed.
Swiss Institute of Bioinformatics
SwissTargetPrediction
Query Molecule






Target Classes
Top 15
Top 25
Top 50
All
Export results:
Target | Common name | Uniprot ID | ChEMBL ID | Target Class | Probability* | Known actives (3D/2D) |
---|---|---|---|---|---|---|
Serotonin transporter | SLC6A4 | P31645 | CHEMBL228 | Electrochemical transporter | 0.697501031388 |
1062 /
298   |
Dopamine transporter | SLC6A3 | Q01959 | CHEMBL238 | Electrochemical transporter | 0.670876754555 |
821 /
77   |
Serotonin 2b (5-HT2b) receptor | HTR2B | P41595 | CHEMBL1833 | Family A G protein-coupled receptor | 0.661620920662 |
85 /
51   |
Serotonin 1a (5-HT1a) receptor | HTR1A | P08908 | CHEMBL214 | Family A G protein-coupled receptor | 0.661620920662 |
161 /
195   |
Serotonin 2a (5-HT2a) receptor | HTR2A | P28223 | CHEMBL224 | Family A G protein-coupled receptor | 0.661620920662 |
419 /
215   |
Serotonin 2c (5-HT2c) receptor | HTR2C | P28335 | CHEMBL225 | Family A G protein-coupled receptor | 0.661620920662 |
241 /
131   |
Serotonin 6 (5-HT6) receptor | HTR6 | P50406 | CHEMBL3371 | Family A G protein-coupled receptor | 0.462007056192 |
362 /
215   |
Serotonin 1d (5-HT1d) receptor | HTR1D | P28221 | CHEMBL1983 | Family A G protein-coupled receptor | 0.316824689204 |
100 /
312   |
Serotonin 1b (5-HT1b) receptor | HTR1B | P28222 | CHEMBL1898 | Family A G protein-coupled receptor | 0.316824689204 |
107 /
288   |
Norepinephrine transporter | SLC6A2 | P23975 | CHEMBL222 | Electrochemical transporter | 0.171518552462 |
646 /
73   |
Alpha-2a adrenergic receptor | ADRA2A | P08913 | CHEMBL1867 | Family A G protein-coupled receptor | 0.162404208274 |
36 /
11   |
Adrenergic receptor alpha-2 | ADRA2C | P18825 | CHEMBL1916 | Family A G protein-coupled receptor | 0.162404208274 |
32 /
9   |
Alpha-2b adrenergic receptor | ADRA2B | P18089 | CHEMBL1942 | Family A G protein-coupled receptor | 0.162404208274 |
29 /
10   |
Serotonin 1e (5-HT1e) receptor | HTR1E | P28566 | CHEMBL2182 | Family A G protein-coupled receptor | 0.162404208274 |
7 /
12   |
Alpha-1a adrenergic receptor | ADRA1A | P35348 | CHEMBL229 | Family A G protein-coupled receptor | 0.162404208274 |
55 /
39   |
Histamine H1 receptor | HRH1 | P35367 | CHEMBL231 | Family A G protein-coupled receptor | 0.162404208274 |
100 /
8   |
Alpha-1b adrenergic receptor | ADRA1B | P35368 | CHEMBL232 | Family A G protein-coupled receptor | 0.162404208274 |
8 /
9   |
Dopamine D3 receptor | DRD3 | P35462 | CHEMBL234 | Family A G protein-coupled receptor | 0.162404208274 |
189 /
88   |
Kappa Opioid receptor | OPRK1 | P41145 | CHEMBL237 | Family A G protein-coupled receptor | 0.162404208274 |
32 /
45   |
Sigma opioid receptor | SIGMAR1 | Q99720 | CHEMBL287 | Membrane receptor | 0.162404208274 |
358 /
48   |
Myeloperoxidase | MPO | P05164 | CHEMBL2439 | Enzyme | 0.126154249845 |
21 /
49   |
Serotonin 7 (5-HT7) receptor | HTR7 | P34969 | CHEMBL3155 | Family A G protein-coupled receptor | 0.117056357516 |
92 /
57   |
Dopamine D2 receptor | DRD2 | P14416 | CHEMBL217 | Family A G protein-coupled receptor | 0.0807923867549 |
436 /
252   |
Beta-1 adrenergic receptor | ADRB1 | P08588 | CHEMBL213 | Family A G protein-coupled receptor | 0.0807923867549 |
6 /
13   |
Dopamine D1 receptor | DRD1 | P21728 | CHEMBL2056 | Family A G protein-coupled receptor | 0.071715932485 |
36 /
25   |
Serotonin 5a (5-HT5a) receptor | HTR5A | P47898 | CHEMBL3426 | Family A G protein-coupled receptor | 0.071715932485 |
20 /
33   |
Mu opioid receptor | OPRM1 | P35372 | CHEMBL233 | Family A G protein-coupled receptor | 0.0626219668353 |
62 /
119   |
Transient receptor potential cation channel subfamily M member 8 (by homology) | TRPM8 | Q7Z2W7 | CHEMBL1075319 | Voltage-gated ion channel | 0.0626219668353 |
1 /
1   |
Histamine H3 receptor | HRH3 | Q9Y5N1 | CHEMBL264 | Family A G protein-coupled receptor | 0.0626219668353 |
142 /
25   |
Adenosine A3 receptor | ADORA3 | P0DMS8 | CHEMBL256 | Family A G protein-coupled receptor | 0.0626219668353 |
3 /
1   |
Alpha-1d adrenergic receptor | ADRA1D | P25100 | CHEMBL223 | Family A G protein-coupled receptor | 0.0626219668353 |
20 /
10   |
Melatonin receptor 1A | MTNR1A | P48039 | CHEMBL1945 | Family A G protein-coupled receptor | 0.0626219668353 |
0 /
120   |
Melatonin receptor 1B | MTNR1B | P49286 | CHEMBL1946 | Family A G protein-coupled receptor | 0.0626219668353 |
0 /
110   |
Serotonin 3a (5-HT3a) receptor | HTR3A | P46098 | CHEMBL1899 | Ligand-gated ion channel | 0.0535560755162 |
59 /
11   |
Histamine H2 receptor | HRH2 | P25021 | CHEMBL1941 | Family A G protein-coupled receptor | 0.0535560755162 |
25 /
1   |
Dopamine D5 receptor | DRD5 | P21918 | CHEMBL1850 | Family A G protein-coupled receptor | 0.0535560755162 |
21 /
20   |
Dopamine D4 receptor | DRD4 | P21917 | CHEMBL219 | Family A G protein-coupled receptor | 0.0535560755162 |
107 /
26   |
Acetylcholinesterase | ACHE | P22303 | CHEMBL220 | Hydrolase | 0.0535560755162 |
20 /
51   |
DNA (cytosine-5)-methyltransferase 1 (by homology) | DNMT1 | P26358 | CHEMBL1993 | Writer | 0.0535560755162 |
0 /
3   |
Melanocortin receptor 5 | MC5R | P33032 | CHEMBL4608 | Family A G protein-coupled receptor | 0.0535560755162 |
2 /
48   |
HERG | KCNH2 | Q12809 | CHEMBL240 | Voltage-gated ion channel | 0.0535560755162 |
186 /
45   |
Interferon-alpha/beta receptor alpha chain | IFNAR1 | P17181 | CHEMBL1887 | Membrane receptor | 0.0535560755162 |
1 /
0   |
Squalene synthetase (by homology) | FDFT1 | P37268 | CHEMBL3338 | Enzyme | 0.0535560755162 |
10 /
0   |
Vanilloid receptor | TRPV1 | Q8NER1 | CHEMBL4794 | Voltage-gated ion channel | 0.0535560755162 |
1 /
12   |
Serotonin 4 (5-HT4) receptor | HTR4 | Q13639 | CHEMBL1875 | Family A G protein-coupled receptor | 0.0535560755162 |
1 /
11   |
Nociceptin receptor | OPRL1 | P41146 | CHEMBL2014 | Family A G protein-coupled receptor | 0.0535560755162 |
41 /
25   |
Tyrosine-protein kinase FYN | FYN | P06241 | CHEMBL1841 | Kinase | 0.0535560755162 |
3 /
0   |
Muscarinic acetylcholine receptor M5 | CHRM5 | P08912 | CHEMBL2035 | Family A G protein-coupled receptor | 0.0535560755162 |
46 /
0   |
Potassium channel subfamily K member 2 | KCNK2 | O95069 | CHEMBL2321615 | Voltage-gated ion channel | 0.0535560755162 |
1 /
0   |
Prion protein | PRNP | P04156 | CHEMBL4869 | Surface antigen | 0.0535560755162 |
4 /
0   |
Calmodulin | CALM1 | P62158 | CHEMBL6093 | Unclassified protein | 0.0535560755162 |
1 /
0   |
Cyclooxygenase-1 (by homology) | PTGS1 | P23219 | CHEMBL221 | Oxidoreductase | 0.0535560755162 |
1 /
0   |
Melanocortin receptor 4 | MC4R | P32245 | CHEMBL259 | Family A G protein-coupled receptor | 0.0535560755162 |
0 /
88   |
Matrix metalloproteinase 9 | MMP9 | P14780 | CHEMBL321 | Protease | 0.0535560755162 |
0 /
23   |
Melanocortin receptor 1 (by homology) | MC1R | Q01726 | CHEMBL3795 | Family A G protein-coupled receptor | 0.0535560755162 |
0 /
71   |
Neuronal acetylcholine receptor; alpha4/beta2 | CHRNA4 CHRNB2 | P43681 P17787 | CHEMBL1907589 | Ligand-gated ion channel | 0.0535560755162 |
41 /
6   |
Kinesin-1 heavy chain/ Tyrosine-protein kinase receptor RET | RET | P07949 | CHEMBL2041 | Kinase | 0.0535560755162 |
4 /
0   |
Neuronal acetylcholine receptor protein alpha-7 subunit | CHRNA7 | P36544 | CHEMBL2492 | Ligand-gated ion channel | 0.0535560755162 |
21 /
9   |
Cyclin-dependent kinase 4/cyclin D1 | CCND1 CDK4 | P24385 P11802 | CHEMBL1907601 | Kinase | 0.0535560755162 |
0 /
23   |
Cyclin-dependent kinase 4 | CDK4 | P11802 | CHEMBL331 | Kinase | 0.0535560755162 |
0 /
3   |
Butyrylcholinesterase | BCHE | P06276 | CHEMBL1914 | Hydrolase | 0.0535560755162 |
10 /
43   |
Anandamide amidohydrolase | FAAH | O00519 | CHEMBL2243 | Enzyme | 0.0535560755162 |
0 /
1   |
Muscarinic acetylcholine receptor M1 | CHRM1 | P11229 | CHEMBL216 | Family A G protein-coupled receptor | 0.0535560755162 |
137 /
2   |
LSD1/CoREST complex | RCOR1 KDM1A | Q9UKL0 O60341 | CHEMBL3137262 | Eraser | 0.0535560755162 |
13 /
0   |
Kinesin-like protein 1 | KIF11 | P52732 | CHEMBL4581 | Other cytosolic protein | 0.0535560755162 |
48 /
23   |
Neurokinin 1 receptor | TACR1 | P25103 | CHEMBL249 | Family A G protein-coupled receptor | 0.0535560755162 |
7 /
83   |
Melanocortin receptor 3 | MC3R | P41968 | CHEMBL4644 | Family A G protein-coupled receptor | 0.0535560755162 |
0 /
47   |
Quinone reductase 2 | NQO2 | P16083 | CHEMBL3959 | Enzyme | 0.0535560755162 |
1 /
14   |
Sodium channel protein type IX alpha subunit | SCN9A | Q15858 | CHEMBL4296 | Voltage-gated ion channel | 0.0 |
1 /
0   |
Glutamate [NMDA] receptor subunit epsilon 2 | GRIN2B | Q13224 | CHEMBL1904 | Ligand-gated ion channel | 0.0 |
14 /
1   |
Cytochrome P450 2C19 | CYP2C19 | P33261 | CHEMBL3622 | Cytochrome P450 | 0.0 |
3 /
0   |
Beta-3 adrenergic receptor | ADRB3 | P13945 | CHEMBL246 | Family A G protein-coupled receptor | 0.0 |
0 /
6   |
Nischarin | NISCH | Q9Y2I1 | CHEMBL3923 | Other cytosolic protein | 0.0 |
0 /
4   |
GABA receptor alpha-5 subunit (by homology) | GABRA5 | P31644 | CHEMBL5112 | Ligand-gated ion channel | 0.0 |
0 /
9   |
GABA receptor alpha-1 subunit (by homology) | GABRA1 | P14867 | CHEMBL1962 | Ligand-gated ion channel | 0.0 |
0 /
11   |
Lysosomal Pro-X carboxypeptidase | PRCP | P42785 | CHEMBL2335 | Protease | 0.0 |
13 /
0   |
Histone-lysine N-methyltransferase SETD7 | SETD7 | Q8WTS6 | CHEMBL5523 | Writer | 0.0 |
2 /
0   |
S-100 protein beta chain | S100B | P04271 | CHEMBL4300 | Other cytosolic protein | 0.0 |
1 /
0   |
Monoamine oxidase A | MAOA | P21397 | CHEMBL1951 | Oxidoreductase | 0.0 |
45 /
4   |
Monoamine oxidase B | MAOB | P27338 | CHEMBL2039 | Oxidoreductase | 0.0 |
39 /
4   |
Cytochrome P450 51 | CYP51A1 | Q16850 | CHEMBL3849 | Cytochrome P450 | 0.0 |
0 /
3   |
Phenylethanolamine N-methyltransferase | PNMT | P11086 | CHEMBL4617 | Enzyme | 0.0 |
8 /
0   |
Multidrug and toxin extrusion protein 1 | SLC47A1 | Q96FL8 | CHEMBL1743126 | Electrochemical transporter | 0.0 |
0 /
1   |
Myosin light chain kinase, smooth muscle | MYLK | Q15746 | CHEMBL2428 | Kinase | 0.0 |
3 /
0   |
C-X-C chemokine receptor type 3 | CXCR3 | P49682 | CHEMBL4441 | Family A G protein-coupled receptor | 0.0 |
16 /
0   |
Adenosine A2a receptor | ADORA2A | P29274 | CHEMBL251 | Family A G protein-coupled receptor | 0.0 |
0 /
4   |
Neurokinin 3 receptor | TACR3 | P29371 | CHEMBL4429 | Family A G protein-coupled receptor | 0.0 |
0 /
6   |
Endothelin-converting enzyme 1 | ECE1 | P42892 | CHEMBL4791 | Protease | 0.0 |
0 /
28   |
Nuclear receptor subfamily 1 group D member 2 | NR1D2 | Q14995 | CHEMBL1961784 | Nuclear receptor | 0.0 |
1 /
0   |
Vesicular acetylcholine transporter | SLC18A3 | Q16572 | CHEMBL4767 | Electrochemical transporter | 0.0 |
2 /
0   |
Tyrosinase | TYR | P14679 | CHEMBL1973 | Oxidoreductase | 0.0 |
0 /
1   |
Poly [ADP-ribose] polymerase-1 | PARP1 | P09874 | CHEMBL3105 | Enzyme | 0.0 |
0 /
49   |
Cytochrome P450 1A2 | CYP1A2 | P05177 | CHEMBL3356 | Cytochrome P450 | 0.0 |
1 /
0   |
Glutamate NMDA receptor; GRIN1/GRIN2B | GRIN1 GRIN2B | Q05586 Q13224 | CHEMBL1907603 | Ligand-gated ion channel | 0.0 |
1 /
0   |
Calcium sensing receptor | CASR | P41180 | CHEMBL1878 | Family C G protein-coupled receptor | 0.0 |
2 /
0   |
Histamine H4 receptor | HRH4 | Q9H3N8 | CHEMBL3759 | Family A G protein-coupled receptor | 0.0 |
81 /
0   |
Anti-estrogen binding site (AEBS) | EBP | Q15125 | CHEMBL4931 | Enzyme | 0.0 |
4 /
0   |
Voltage-gated potassium channel subunit Kv1.3 | KCNA3 | P22001 | CHEMBL4633 | Voltage-gated ion channel | 0.0 |
3 /
0   |
Vascular endothelial growth factor receptor 3 | FLT4 | P35916 | CHEMBL1955 | Kinase | 0.0 |
0 /
7   |
Insulin-like growth factor I receptor | IGF1R | P08069 | CHEMBL1957 | Kinase | 0.0 |
0 /
9   |
*Probability for the query molecule - assumed as bioactive - to have this protein as target.