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Swiss Institute of Bioinformatics
SwissTargetPrediction
Query Molecule
Target Classes
Top 15
Top 25
Top 50
All
Export results:
| Target | Common name | Uniprot ID | ChEMBL ID | Target Class | Probability* | Known actives (3D/2D) |
|---|---|---|---|---|---|---|
| GABA transporter 1 (by homology) | SLC6A1 | P30531 | CHEMBL1903 | Electrochemical transporter | 0.113285953487 |
211 /
0 |
| C-C chemokine receptor type 5 | CCR5 | P51681 | CHEMBL274 | Family A G protein-coupled receptor | 0.113285953487 |
6 /
0 |
| Norepinephrine transporter | SLC6A2 | P23975 | CHEMBL222 | Electrochemical transporter | 0.113285953487 |
6 /
0 |
| Rho-associated protein kinase 2 | ROCK2 | O75116 | CHEMBL2973 | Kinase | 0.113285953487 |
8 /
0 |
| Delta opioid receptor | OPRD1 | P41143 | CHEMBL236 | Family A G protein-coupled receptor | 0.113285953487 |
102 /
0 |
| Peroxisome proliferator-activated receptor delta | PPARD | Q03181 | CHEMBL3979 | Nuclear receptor | 0.113285953487 |
24 /
0 |
| Sphingosine 1-phosphate receptor Edg-8 | S1PR5 | Q9H228 | CHEMBL2274 | Family A G protein-coupled receptor | 0.113285953487 |
41 /
0 |
| Sphingosine 1-phosphate receptor Edg-1 | S1PR1 | P21453 | CHEMBL4333 | Family A G protein-coupled receptor | 0.113285953487 |
83 /
0 |
| Estrogen receptor alpha | ESR1 | P03372 | CHEMBL206 | Nuclear receptor | 0.113285953487 |
59 /
0 |
| Integrin alpha-V/beta-3 | ITGAV ITGB3 | P06756 P05106 | CHEMBL1907598 | Membrane receptor | 0.113285953487 |
187 /
0 |
| Integrin alpha-5/beta-1 | ITGB1 ITGA5 | P05556 P08648 | CHEMBL2095226 | Membrane receptor | 0.113285953487 |
9 /
0 |
| Phosphodiesterase 7A | PDE7A | Q13946 | CHEMBL3012 | Phosphodiesterase | 0.113285953487 |
5 /
0 |
| Endothelin receptor ET-A (by homology) | EDNRA | P25101 | CHEMBL252 | Family A G protein-coupled receptor | 0.113285953487 |
212 /
0 |
| Carboxypeptidase B2 isoform A | CPB2 | Q96IY4 | CHEMBL3419 | Protease | 0.113285953487 |
37 /
0 |
| Mu opioid receptor | OPRM1 | P35372 | CHEMBL233 | Family A G protein-coupled receptor | 0.113285953487 |
101 /
0 |
| Dipeptidyl peptidase IV | DPP4 | P27487 | CHEMBL284 | Protease | 0.113285953487 |
135 /
0 |
| Prolyl endopeptidase | PREP | P48147 | CHEMBL3202 | Protease | 0.113285953487 |
5 /
0 |
| Dipeptidyl peptidase II | DPP7 | Q9UHL4 | CHEMBL3976 | Protease | 0.113285953487 |
10 /
0 |
| Dipeptidyl peptidase VIII | DPP8 | Q6V1X1 | CHEMBL4657 | Protease | 0.113285953487 |
12 /
0 |
| Fibroblast activation protein alpha | FAP | Q12884 | CHEMBL4683 | Protease | 0.113285953487 |
5 /
0 |
| Dipeptidyl peptidase IX | DPP9 | Q86TI2 | CHEMBL4793 | Protease | 0.113285953487 |
11 /
0 |
| Progesterone receptor | PGR | P06401 | CHEMBL208 | Nuclear receptor | 0.113285953487 |
12 /
0 |
| Histamine H1 receptor | HRH1 | P35367 | CHEMBL231 | Family A G protein-coupled receptor | 0.113285953487 |
63 /
0 |
| Casein kinase II alpha | CSNK2A1 | P68400 | CHEMBL3629 | Kinase | 0.113285953487 |
75 /
0 |
| Lethal(3)malignant brain tumor-like protein 3 | L3MBTL3 | Q96JM7 | CHEMBL1287623 | Reader | 0.113285953487 |
1 /
0 |
| 11-beta-hydroxysteroid dehydrogenase 2 | HSD11B2 | P80365 | CHEMBL3746 | Enzyme | 0.113285953487 |
3 /
0 |
| Leukotriene A4 hydrolase | LTA4H | P09960 | CHEMBL4618 | Protease | 0.113285953487 |
74 /
0 |
| Mineralocorticoid receptor | NR3C2 | P08235 | CHEMBL1994 | Nuclear receptor | 0.113285953487 |
3 /
0 |
| Prostanoid IP receptor | PTGIR | P43119 | CHEMBL1995 | Family A G protein-coupled receptor | 0.113285953487 |
26 /
0 |
| Glycine transporter 1 | SLC6A9 | P48067 | CHEMBL2337 | Electrochemical transporter | 0.113285953487 |
85 /
0 |
| Lysine-specific demethylase 5A | KDM5A | P29375 | CHEMBL2424504 | Eraser | 0.113285953487 |
8 /
0 |
| Serine/threonine-protein kinase PIM2 | PIM2 | Q9P1W9 | CHEMBL4523 | Kinase | 0.113285953487 |
23 /
0 |
| Cytochrome P450 26A1 | CYP26A1 | O43174 | CHEMBL5141 | Cytochrome P450 | 0.113285953487 |
11 /
0 |
| Serine/threonine-protein kinase PLK1 | PLK1 | P53350 | CHEMBL3024 | Kinase | 0.113285953487 |
14 /
0 |
| Adrenergic receptor alpha-2 | ADRA2C | P18825 | CHEMBL1916 | Family A G protein-coupled receptor | 0.113285953487 |
2 /
0 |
| Tyrosine-protein kinase JAK1 | JAK1 | P23458 | CHEMBL2835 | Kinase | 0.113285953487 |
4 /
0 |
| Dopamine D1 receptor | DRD1 | P21728 | CHEMBL2056 | Family A G protein-coupled receptor | 0.113285953487 |
4 /
0 |
| Dopamine D2 receptor | DRD2 | P14416 | CHEMBL217 | Family A G protein-coupled receptor | 0.113285953487 |
9 /
0 |
| Leucine aminopeptidase | LAP3 | P28838 | CHEMBL3965 | Protease | 0.113285953487 |
6 /
0 |
| Lysine-specific demethylase 4C | KDM4C | Q9H3R0 | CHEMBL6175 | Eraser | 0.113285953487 |
15 /
0 |
| Prostanoid EP2 receptor | PTGER2 | P43116 | CHEMBL1881 | Family A G protein-coupled receptor | 0.113285953487 |
129 /
0 |
| Integrin alpha-4/beta-7 | ITGB7 ITGA4 | P26010 P13612 | CHEMBL2095184 | Membrane receptor | 0.113285953487 |
34 /
0 |
| Integrin alpha-2/beta-3 | ITGA2 ITGB3 | P17301 P05106 | CHEMBL2111461 | Membrane receptor | 0.113285953487 |
12 /
0 |
| Calcium sensing receptor | CASR | P41180 | CHEMBL1878 | Family C G protein-coupled receptor | 0.113285953487 |
29 /
0 |
| Aminopeptidase B | RNPEP | Q9H4A4 | CHEMBL2432 | Protease | 0.113285953487 |
3 /
0 |
| Nociceptin receptor | OPRL1 | P41146 | CHEMBL2014 | Family A G protein-coupled receptor | 0.113285953487 |
8 /
0 |
| Epidermal growth factor receptor erbB1 | EGFR | P00533 | CHEMBL203 | Kinase | 0.113285953487 |
28 /
0 |
| Integrin alpha-IIb/beta-3 | ITGA2B ITGB3 | P08514 P05106 | CHEMBL2093869 | Membrane receptor | 0.113285953487 |
143 /
0 |
| MAP kinase p38 alpha | MAPK14 | Q16539 | CHEMBL260 | Kinase | 0.113285953487 |
33 /
0 |
| MAP kinase p38 beta | MAPK11 | Q15759 | CHEMBL3961 | Kinase | 0.113285953487 |
1 /
0 |
| Opioid growth factor receptor-like protein 1 | OGFRL1 | Q5TC84 | CHEMBL3638334 | Unclassified protein | 0.113285953487 |
16 /
0 |
| Thrombin and coagulation factor X | F10 | P00742 | CHEMBL244 | Protease | 0.113285953487 |
18 /
0 |
| Cyclin-dependent kinase 9 | CDK9 | P50750 | CHEMBL3116 | Kinase | 0.113285953487 |
10 /
0 |
| Adrenergic receptor beta | ADRB2 | P07550 | CHEMBL210 | Family A G protein-coupled receptor | 0.113285953487 |
3 /
0 |
| Beta-1 adrenergic receptor | ADRB1 | P08588 | CHEMBL213 | Family A G protein-coupled receptor | 0.113285953487 |
4 /
0 |
| Retinoid X receptor alpha | RXRA | P19793 | CHEMBL2061 | Nuclear receptor | 0.113285953487 |
13 /
0 |
| Leukotriene B4 receptor 1 | LTB4R | Q15722 | CHEMBL3911 | Family A G protein-coupled receptor | 0.113285953487 |
8 /
0 |
| Receptor-type tyrosine-protein phosphatase alpha | PTPRA | P18433 | CHEMBL3918 | Phosphatase | 0.113285953487 |
2 /
0 |
| Inhibitor of apoptosis protein 3 | XIAP | P98170 | CHEMBL4198 | Other cytosolic protein | 0.113285953487 |
9 /
0 |
| Tryptophan 5-hydroxylase 1 | TPH1 | P17752 | CHEMBL5689 | Enzyme | 0.113285953487 |
40 /
0 |
| Sodium channel protein type IX alpha subunit | SCN9A | Q15858 | CHEMBL4296 | Voltage-gated ion channel | 0.113285953487 |
1 /
0 |
| Carboxypeptidase B | CPB1 | P15086 | CHEMBL2552 | Protease | 0.113285953487 |
11 /
0 |
| Endothelin receptor ET-B | EDNRB | P24530 | CHEMBL1785 | Family A G protein-coupled receptor | 0.113285953487 |
80 /
0 |
| Inosine-5'-monophosphate dehydrogenase 2 | IMPDH2 | P12268 | CHEMBL2002 | Oxidoreductase | 0.113285953487 |
43 /
0 |
| Tyrosine-protein kinase SRC | SRC | P12931 | CHEMBL267 | Kinase | 0.113285953487 |
25 /
0 |
| Squalene synthetase | FDFT1 | P37268 | CHEMBL3338 | Enzyme | 0.0 |
9 /
0 |
| Inosine-5'-monophosphate dehydrogenase 1 | IMPDH1 | P20839 | CHEMBL1822 | Oxidoreductase | 0.0 |
17 /
0 |
| Thromboxane A2 receptor | TBXA2R | P21731 | CHEMBL2069 | Family A G protein-coupled receptor | 0.0 |
89 /
0 |
| Peroxisome proliferator-activated receptor gamma | PPARG | P37231 | CHEMBL235 | Nuclear receptor | 0.0 |
38 /
0 |
| Insulin-degrading enzyme | IDE | P14735 | CHEMBL1293287 | Enzyme | 0.0 |
6 /
0 |
| Thrombin | F2 | P00734 | CHEMBL204 | Protease | 0.0 |
22 /
0 |
| NAD-dependent deacetylase sirtuin 1 | SIRT1 | Q96EB6 | CHEMBL4506 | Eraser | 0.0 |
3 /
0 |
| Kinesin-like protein 1 | KIF11 | P52732 | CHEMBL4581 | Other cytosolic protein | 0.0 |
60 /
0 |
| Probable G-protein coupled receptor 142 | GPR142 | Q7Z601 | CHEMBL2069161 | Family A G protein-coupled receptor | 0.0 |
4 /
0 |
| C-C chemokine receptor type 3 | CCR3 | P51677 | CHEMBL3473 | Family A G protein-coupled receptor | 0.0 |
33 /
0 |
| Histone deacetylase 1 | HDAC1 | Q13547 | CHEMBL325 | Eraser | 0.0 |
5 /
0 |
| HMG-CoA reductase (by homology) | HMGCR | P04035 | CHEMBL402 | Oxidoreductase | 0.0 |
279 /
0 |
| Muscarinic acetylcholine receptor M1 (by homology) | CHRM1 | P11229 | CHEMBL216 | Family A G protein-coupled receptor | 0.0 |
1 /
0 |
| Autotaxin | ENPP2 | Q13822 | CHEMBL3691 | Enzyme | 0.0 |
5 /
0 |
| Serine/threonine-protein kinase Chk1 | CHEK1 | O14757 | CHEMBL4630 | Kinase | 0.0 |
7 /
0 |
| Serine/threonine-protein kinase WEE1 | WEE1 | P30291 | CHEMBL5491 | Kinase | 0.0 |
4 /
0 |
| Tyrosine-protein kinase JAK3 | JAK3 | P52333 | CHEMBL2148 | Kinase | 0.0 |
3 /
0 |
| Serotonin 3a (5-HT3a) receptor (by homology) | HTR3A | P46098 | CHEMBL1899 | Ligand-gated ion channel | 0.0 |
6 /
0 |
| Thyroid hormone receptor alpha | THRA | P10827 | CHEMBL1860 | Nuclear receptor | 0.0 |
114 /
0 |
| Neprilysin | MME | P08473 | CHEMBL1944 | Protease | 0.0 |
58 /
0 |
| Thyroid hormone receptor beta-1 | THRB | P10828 | CHEMBL1947 | Nuclear receptor | 0.0 |
128 /
0 |
| Glutamate receptor ionotropic kainate 1 | GRIK1 | P39086 | CHEMBL1918 | Ligand-gated ion channel | 0.0 |
26 /
0 |
| Beta-3 adrenergic receptor | ADRB3 | P13945 | CHEMBL246 | Family A G protein-coupled receptor | 0.0 |
7 /
0 |
| Glutamate receptor ionotropic, AMPA 2 | GRIA2 | P42262 | CHEMBL4016 | Ligand-gated ion channel | 0.0 |
16 /
0 |
| Disks large homolog 4 | DLG4 | P78352 | CHEMBL5666 | Unclassified protein | 0.0 |
11 /
0 |
| MAP kinase signal-integrating kinase 2 | MKNK2 | Q9HBH9 | CHEMBL4204 | Kinase | 0.0 |
6 /
0 |
| Caspase-1 | CASP1 | P29466 | CHEMBL4801 | Protease | 0.0 |
52 /
0 |
| Lysine-specific demethylase 5C | KDM5C | P41229 | CHEMBL2163176 | Eraser | 0.0 |
2 /
0 |
| Transthyretin | TTR | P02766 | CHEMBL3194 | Secreted protein | 0.0 |
3 /
0 |
| Lysine-specific demethylase 5B | KDM5B | Q9UGL1 | CHEMBL3774295 | Eraser | 0.0 |
2 /
0 |
| Lysine-specific demethylase 2B | KDM2B | Q8NHM5 | CHEMBL3779760 | Eraser | 0.0 |
1 /
0 |
| Glycogen synthase kinase-3 beta | GSK3B | P49841 | CHEMBL262 | Kinase | 0.0 |
32 /
0 |
| Poly [ADP-ribose] polymerase-1 | PARP1 | P09874 | CHEMBL3105 | Enzyme | 0.0 |
8 /
0 |
| Integrin alpha-V/beta-5 | ITGB5 ITGAV | P18084 P06756 | CHEMBL2096675 | Membrane receptor | 0.0 |
34 /
0 |
| Integrin alpha-V/beta-1 | ITGAV ITGB1 | P06756 P05556 | CHEMBL2111407 | Membrane receptor | 0.0 |
16 /
0 |
*Probability for the query molecule - assumed as bioactive - to have this protein as target.