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Swiss Institute of Bioinformatics
SwissTargetPrediction
Query Molecule






Target Classes
Top 15
Top 25
Top 50
All
Export results:
Target | Common name | Uniprot ID | ChEMBL ID | Target Class | Probability* | Known actives (3D/2D) |
---|---|---|---|---|---|---|
Serotonin 2a (5-HT2a) receptor | HTR2A | P28223 | CHEMBL224 | Family A G protein-coupled receptor | 0.519923086957 |
308 /
161   |
Serotonin 2b (5-HT2b) receptor | HTR2B | P41595 | CHEMBL1833 | Family A G protein-coupled receptor | 0.112450964818 |
152 /
11   |
Serotonin 2c (5-HT2c) receptor | HTR2C | P28335 | CHEMBL225 | Family A G protein-coupled receptor | 0.112450964818 |
233 /
36   |
Serotonin 1a (5-HT1a) receptor | HTR1A | P08908 | CHEMBL214 | Family A G protein-coupled receptor | 0.103761755413 |
160 /
110   |
Serine/threonine-protein kinase AKT | AKT1 | P31749 | CHEMBL4282 | Kinase | 0.0690974435253 |
43 /
17   |
Serine/threonine-protein kinase PIM1 | PIM1 | P11309 | CHEMBL2147 | Kinase | 0.0604245879294 |
12 /
0   |
Serine/threonine-protein kinase PIM2 | PIM2 | Q9P1W9 | CHEMBL4523 | Kinase | 0.0604245879294 |
10 /
0   |
Serine/threonine-protein kinase PIM3 | PIM3 | Q86V86 | CHEMBL5407 | Kinase | 0.0604245879294 |
5 /
0   |
Rho-associated protein kinase 2 | ROCK2 | O75116 | CHEMBL2973 | Kinase | 0.0604245879294 |
52 /
0   |
Gamma-amino-N-butyrate transaminase (by homology) | ABAT | P80404 | CHEMBL2044 | Transferase | 0.0604245879294 |
7 /
0   |
Neuronal acetylcholine receptor protein alpha-4 subunit | CHRNA4 | P43681 | CHEMBL1882 | Ligand-gated ion channel | 0.0604245879294 |
38 /
0   |
Thrombin | F2 | P00734 | CHEMBL204 | Protease | 0.0604245879294 |
16 /
0   |
Inhibitor of nuclear factor kappa B kinase beta subunit | IKBKB | O14920 | CHEMBL1991 | Kinase | 0.0604245879294 |
23 /
0   |
Histamine H2 receptor | HRH2 | P25021 | CHEMBL1941 | Family A G protein-coupled receptor | 0.0604245879294 |
7 /
0   |
Muscarinic acetylcholine receptor M5 | CHRM5 | P08912 | CHEMBL2035 | Family A G protein-coupled receptor | 0.0604245879294 |
10 /
0   |
Serotonin 6 (5-HT6) receptor | HTR6 | P50406 | CHEMBL3371 | Family A G protein-coupled receptor | 0.0604245879294 |
158 /
0   |
Huntingtin | HTT | P42858 | CHEMBL5514 | Unclassified protein | 0.0604245879294 |
2 /
0   |
Protein arginine N-methyltransferase 3 | PRMT3 | O60678 | CHEMBL5891 | Writer | 0.0604245879294 |
3 /
0   |
Dipeptidyl peptidase IV | DPP4 | P27487 | CHEMBL284 | Protease | 0.0604245879294 |
299 /
0   |
Dopamine D2 receptor | DRD2 | P14416 | CHEMBL217 | Family A G protein-coupled receptor | 0.0604245879294 |
379 /
194   |
Dipeptidyl peptidase II | DPP7 | Q9UHL4 | CHEMBL3976 | Protease | 0.0604245879294 |
76 /
0   |
Dipeptidyl peptidase VIII | DPP8 | Q6V1X1 | CHEMBL4657 | Protease | 0.0604245879294 |
60 /
0   |
Fibroblast activation protein alpha | FAP | Q12884 | CHEMBL4683 | Protease | 0.0604245879294 |
14 /
0   |
Dipeptidyl peptidase IX | DPP9 | Q86TI2 | CHEMBL4793 | Protease | 0.0604245879294 |
42 /
0   |
Nitric oxide synthase, inducible | NOS2 | P35228 | CHEMBL4481 | Enzyme | 0.0604245879294 |
28 /
0   |
Serotonin 1f (5-HT1f) receptor | HTR1F | P30939 | CHEMBL1805 | Family A G protein-coupled receptor | 0.0604245879294 |
12 /
0   |
Nitric-oxide synthase, brain | NOS1 | P29475 | CHEMBL3568 | Enzyme | 0.0604245879294 |
25 /
0   |
Nitric-oxide synthase, endothelial | NOS3 | P29474 | CHEMBL4803 | Enzyme | 0.0604245879294 |
11 /
0   |
Dihydropteridine reductase | QDPR | P09417 | CHEMBL3730 | Enzyme | 0.0604245879294 |
6 /
0   |
Rho-associated protein kinase 1 | ROCK1 | Q13464 | CHEMBL3231 | Kinase | 0.0604245879294 |
15 /
0   |
Protein arginine N-methyltransferase 6 | PRMT6 | Q96LA8 | CHEMBL1275221 | Writer | 0.0604245879294 |
8 /
0   |
Protein arginine N-methyltransferase 8 | PRMT8 | Q9NR22 | CHEMBL3108648 | Writer | 0.0604245879294 |
7 /
0   |
Protein-arginine N-methyltransferase 1 | PRMT1 | Q99873 | CHEMBL5524 | Writer | 0.0604245879294 |
6 /
0   |
Tyrosine-protein kinase JAK1 | JAK1 | P23458 | CHEMBL2835 | Kinase | 0.0604245879294 |
22 /
0   |
Tyrosine-protein kinase JAK2 | JAK2 | O60674 | CHEMBL2971 | Kinase | 0.0604245879294 |
17 /
0   |
Trace amine-associated receptor 5 | TAAR5 | O14804 | CHEMBL3714046 | Family A G protein-coupled receptor | 0.0604245879294 |
1 /
0   |
Trace amine-associated receptor 1 | TAAR1 | Q96RJ0 | CHEMBL5857 | Family A G protein-coupled receptor | 0.0604245879294 |
9 /
0   |
Sigma opioid receptor | SIGMAR1 | Q99720 | CHEMBL287 | Membrane receptor | 0.0604245879294 |
172 /
66   |
Tyrosine-protein kinase JAK3 | JAK3 | P52333 | CHEMBL2148 | Kinase | 0.0604245879294 |
6 /
0   |
Carbonic anhydrase IX | CA9 | Q16790 | CHEMBL3594 | Lyase | 0.0604245879294 |
9 /
0   |
C-C chemokine receptor type 5 | CCR5 | P51681 | CHEMBL274 | Family A G protein-coupled receptor | 0.0604245879294 |
2 /
0   |
Serine/threonine-protein kinase Chk1 | CHEK1 | O14757 | CHEMBL4630 | Kinase | 0.0604245879294 |
14 /
0   |
C-C motif chemokine 2 | CCL2 | P13500 | CHEMBL1649052 | Family A G protein-coupled receptor | 0.0604245879294 |
3 /
0   |
Protein kinase N2 | PKN2 | Q16513 | CHEMBL3032 | Kinase | 0.0604245879294 |
4 /
0   |
Protein kinase C epsilon | PRKCE | Q02156 | CHEMBL3582 | Kinase | 0.0604245879294 |
12 /
0   |
Ribosomal protein S6 kinase alpha 5 | RPS6KA5 | O75582 | CHEMBL4237 | Kinase | 0.0604245879294 |
3 /
0   |
Serine/threonine-protein kinase/endoribonuclease IRE1 | ERN1 | O75460 | CHEMBL1163101 | Enzyme | 0.0604245879294 |
1 /
0   |
Lysine-specific demethylase 4D-like | KDM4E | B2RXH2 | CHEMBL1293226 | Eraser | 0.0604245879294 |
1 /
0   |
Tankyrase-2 | TNKS2 | Q9H2K2 | CHEMBL6154 | Enzyme | 0.0604245879294 |
1 /
0   |
Cyclin-dependent kinase 2/cyclin A | CDK2 CCNA1 CCNA2 | P24941 P78396 P20248 | CHEMBL2094128 | Other cytosolic protein | 0.0604245879294 |
2 /
0   |
Cyclin-dependent kinase 2 | CDK2 | P24941 | CHEMBL301 | Kinase | 0.0604245879294 |
4 /
0   |
Adenylate cyclase type V | ADCY5 | O95622 | CHEMBL3189 | Enzyme | 0.0604245879294 |
2 /
0   |
Nischarin | NISCH | Q9Y2I1 | CHEMBL3923 | Other cytosolic protein | 0.0604245879294 |
1 /
0   |
Neuronal acetylcholine receptor subunit alpha-3 | CHRNA3 | P32297 | CHEMBL3068 | Ligand-gated ion channel | 0.0604245879294 |
2 /
0   |
Leucine aminopeptidase | LAP3 | P28838 | CHEMBL3965 | Protease | 0.0604245879294 |
2 /
0   |
Acetylcholine receptor protein alpha chain | CHRNA1 | P02708 | CHEMBL4808 | Ligand-gated ion channel | 0.0604245879294 |
2 /
0   |
NAD-dependent deacetylase sirtuin 1 | SIRT1 | Q96EB6 | CHEMBL4506 | Eraser | 0.0604245879294 |
1 /
0   |
Histone deacetylase 2 | HDAC2 | Q92769 | CHEMBL1937 | Eraser | 0.0 |
1 /
0   |
Histone deacetylase 8 | HDAC8 | Q9BY41 | CHEMBL3192 | Eraser | 0.0 |
5 /
0   |
Histone deacetylase 1 | HDAC1 | Q13547 | CHEMBL325 | Eraser | 0.0 |
14 /
0   |
Serine/threonine-protein kinase haspin | HASPIN | Q8TF76 | CHEMBL1075163 | Kinase | 0.0 |
15 /
0   |
Acetylcholine receptor; alpha1/beta1/delta/gamma | CHRNB1 CHRNA1 CHRNG CHRND | P11230 P02708 P07510 Q07001 | CHEMBL1907588 | Ligand-gated ion channel | 0.0 |
3 /
0   |
Melanocortin receptor 4 | MC4R | P32245 | CHEMBL259 | Family A G protein-coupled receptor | 0.0 |
10 /
0   |
Phosphodiesterase 10A | PDE10A | Q9Y233 | CHEMBL4409 | Phosphodiesterase | 0.0 |
4 /
0   |
PDZ-binding kinase | PBK | Q96KB5 | CHEMBL4896 | Kinase | 0.0 |
3 /
0   |
Serotonin transporter | SLC6A4 | P31645 | CHEMBL228 | Electrochemical transporter | 0.0 |
621 /
33   |
Serotonin 3a (5-HT3a) receptor | HTR3A | P46098 | CHEMBL1899 | Ligand-gated ion channel | 0.0 |
26 /
0   |
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial | AADAT | Q8N5Z0 | CHEMBL2046259 | Enzyme | 0.0 |
37 /
0   |
Dipeptidyl peptidase I | CTSC | P53634 | CHEMBL2252 | Protease | 0.0 |
9 /
0   |
Muscarinic acetylcholine receptor M4 | CHRM4 | P08173 | CHEMBL1821 | Family A G protein-coupled receptor | 0.0 |
12 /
0   |
Muscarinic acetylcholine receptor M2 | CHRM2 | P08172 | CHEMBL211 | Family A G protein-coupled receptor | 0.0 |
21 /
0   |
Muscarinic acetylcholine receptor M1 | CHRM1 | P11229 | CHEMBL216 | Family A G protein-coupled receptor | 0.0 |
40 /
0   |
Muscarinic acetylcholine receptor M3 | CHRM3 | P20309 | CHEMBL245 | Family A G protein-coupled receptor | 0.0 |
13 /
0   |
Myeloperoxidase | MPO | P05164 | CHEMBL2439 | Enzyme | 0.0 |
7 /
0   |
Aminopeptidase N | ANPEP | P15144 | CHEMBL1907 | Protease | 0.0 |
8 /
0   |
Indoleamine 2,3-dioxygenase | IDO1 | P14902 | CHEMBL4685 | Enzyme | 0.0 |
2 /
0   |
Dual specificity protein kinase TTK | TTK | P33981 | CHEMBL3983 | Kinase | 0.0 |
3 /
0   |
Histamine H4 receptor | HRH4 | Q9H3N8 | CHEMBL3759 | Family A G protein-coupled receptor | 0.0 |
33 /
0   |
Carbonic anhydrase VII | CA7 | P43166 | CHEMBL2326 | Lyase | 0.0 |
5 /
0   |
Sodium channel protein type V alpha subunit | SCN5A | Q14524 | CHEMBL1980 | Voltage-gated ion channel | 0.0 |
1 /
0   |
Neurokinin 1 receptor (by homology) | TACR1 | P25103 | CHEMBL249 | Family A G protein-coupled receptor | 0.0 |
20 /
0   |
Sodium channel protein type II alpha subunit | SCN2A | Q99250 | CHEMBL4187 | Voltage-gated ion channel | 0.0 |
1 /
0   |
Phospholipase D1 | PLD1 | Q13393 | CHEMBL2536 | Hydrolase | 0.0 |
1 /
0   |
Protein kinase C delta | PRKCD | Q05655 | CHEMBL2996 | Kinase | 0.0 |
11 /
0   |
Protein kinase C eta | PRKCH | P24723 | CHEMBL3616 | Kinase | 0.0 |
10 /
0   |
Protein kinase C theta | PRKCQ | Q04759 | CHEMBL3920 | Kinase | 0.0 |
13 /
0   |
Serotonin 1b (5-HT1b) receptor | HTR1B | P28222 | CHEMBL1898 | Family A G protein-coupled receptor | 0.0 |
78 /
11   |
Serotonin 1d (5-HT1d) receptor | HTR1D | P28221 | CHEMBL1983 | Family A G protein-coupled receptor | 0.0 |
49 /
1   |
Lethal(3)malignant brain tumor-like protein 3 | L3MBTL3 | Q96JM7 | CHEMBL1287623 | Reader | 0.0 |
3 /
0   |
Protein kinase C beta | PRKCB | P05771 | CHEMBL3045 | Kinase | 0.0 |
6 /
0   |
Histone-arginine methyltransferase CARM1 | CARM1 | Q86X55 | CHEMBL5406 | Writer | 0.0 |
2 /
0   |
Ephrin type-B receptor 3 | EPHB3 | P54753 | CHEMBL4901 | Kinase | 0.0 |
1 /
0   |
Metastin receptor | KISS1R | Q969F8 | CHEMBL5413 | Family A G protein-coupled receptor | 0.0 |
5 /
0   |
Histone acetyltransferase PCAF | KAT2B | Q92831 | CHEMBL5500 | Writer | 0.0 |
6 /
0   |
Serine/threonine-protein kinase Nek1 | NEK1 | Q96PY6 | CHEMBL5855 | Kinase | 0.0 |
15 /
0   |
Inhibitor of apoptosis protein 3 | XIAP | P98170 | CHEMBL4198 | Other cytosolic protein | 0.0 |
12 /
0   |
Dual-specificity tyrosine-phosphorylation regulated kinase 2 | DYRK2 | Q92630 | CHEMBL4376 | Kinase | 0.0 |
4 /
0   |
Baculoviral IAP repeat-containing protein 2 | BIRC2 | Q13490 | CHEMBL5462 | Enzyme | 0.0 |
5 /
0   |
Serotonin 4 (5-HT4) receptor | HTR4 | Q13639 | CHEMBL1875 | Family A G protein-coupled receptor | 0.0 |
12 /
0   |
Protein kinase C alpha | PRKCA | P17252 | CHEMBL299 | Kinase | 0.0 |
4 /
0   |
*Probability for the query molecule - assumed as bioactive - to have this protein as target.