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Query Molecule
Target Classes
Top 15
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Export results:
Target Common name Uniprot ID ChEMBL ID Target Class Probability* Known actives (3D/2D)
Dopamine transporter SLC6A3 Q01959 CHEMBL238 Electrochemical transporter 0.048952897826
 11 / 1     
11-beta-hydroxysteroid dehydrogenase 1 HSD11B1 P28845 CHEMBL4235 Enzyme 0.048952897826
 63 / 28     
Histone deacetylase 6 HDAC6 Q9UBN7 CHEMBL1865 Eraser 0.048952897826
 25 / 0     
Glutaminyl-peptide cyclotransferase-like protein QPCTL Q9NXS2 CHEMBL3638349 Transferase 0.048952897826
 6 / 0     
Adenosine A2b receptor ADORA2B P29275 CHEMBL255 Family A G protein-coupled receptor 0.048952897826
 6 / 0     
Vascular endothelial growth factor receptor 1 FLT1 P17948 CHEMBL1868 Kinase 0.048952897826
 16 / 0     
Vascular endothelial growth factor receptor 2 KDR P35968 CHEMBL279 Kinase 0.048952897826
 62 / 0     
Histone deacetylase 1 HDAC1 Q13547 CHEMBL325 Eraser 0.048952897826
 31 / 4     
Adenosine A3 receptor ADORA3 P0DMS8 CHEMBL256 Family A G protein-coupled receptor 0.048952897826
 16 / 0     
Alpha-1d adrenergic receptor ADRA1D P25100 CHEMBL223 Family A G protein-coupled receptor 0.048952897826
 26 / 0     
Alpha-1b adrenergic receptor ADRA1B P35368 CHEMBL232 Family A G protein-coupled receptor 0.048952897826
 24 / 0     
Metabotropic glutamate receptor 5 GRM5 P41594 CHEMBL3227 Family C G protein-coupled receptor 0.048952897826
 50 / 0     
Metabotropic glutamate receptor 1 GRM1 Q13255 CHEMBL3772 Family C G protein-coupled receptor 0.048952897826
 4 / 0     
Metabotropic glutamate receptor 4 GRM4 Q14833 CHEMBL2736 Family C G protein-coupled receptor 0.048952897826
 2 / 0     
Tyrosine-protein kinase JAK3 JAK3 P52333 CHEMBL2148 Kinase 0.0
 108 / 0     
Tyrosine-protein kinase JAK1 JAK1 P23458 CHEMBL2835 Kinase 0.0
 49 / 0     
Tyrosine-protein kinase JAK2 JAK2 O60674 CHEMBL2971 Kinase 0.0
 86 / 0     
c-Jun N-terminal kinase 1 MAPK8 P45983 CHEMBL2276 Kinase 0.0
 24 / 0     
Adenosine A2a receptor ADORA2A P29274 CHEMBL251 Family A G protein-coupled receptor 0.0
 32 / 0     
Serotonin 2a (5-HT2a) receptor (by homology) HTR2A P28223 CHEMBL224 Family A G protein-coupled receptor 0.0
 21 / 0     
Trace amine-associated receptor 1 (by homology) TAAR1 Q96RJ0 CHEMBL5857 Family A G protein-coupled receptor 0.0
 35 / 0     
Epidermal growth factor receptor erbB1 EGFR P00533 CHEMBL203 Kinase 0.0
 98 / 0     
Prolyl endopeptidase PREP P48147 CHEMBL3202 Protease 0.0
 5 / 0     
Fibroblast activation protein alpha (by homology) FAP Q12884 CHEMBL4683 Protease 0.0
 9 / 0     
G-protein coupled bile acid receptor 1 GPBAR1 Q8TDU6 CHEMBL5409 Family A G protein-coupled receptor 0.0
 16 / 0     
Amine oxidase, copper containing AOC3 Q16853 CHEMBL3437 Enzyme 0.0
 6 / 0     
Androgen Receptor (by homology) AR P10275 CHEMBL1871 Nuclear receptor 0.0
 13 / 0     
C-C chemokine receptor type 5 CCR5 P51681 CHEMBL274 Family A G protein-coupled receptor 0.0
 11 / 0     
Mineralocorticoid receptor NR3C2 P08235 CHEMBL1994 Nuclear receptor 0.0
 36 / 0     
Dihydrofolate reductase DHFR P00374 CHEMBL202 Oxidoreductase 0.0
 21 / 0     
Serine/threonine-protein kinase Aurora-B AURKB Q96GD4 CHEMBL2185 Kinase 0.0
 4 / 0     
Orexin receptor 2 HCRTR2 O43614 CHEMBL4792 Family A G protein-coupled receptor 0.0
 45 / 0     
Orexin receptor 1 HCRTR1 O43613 CHEMBL5113 Family A G protein-coupled receptor 0.0
 40 / 0     
Sigma opioid receptor SIGMAR1 Q99720 CHEMBL287 Membrane receptor 0.0
 14 / 0     
Bile acid receptor FXR NR1H4 Q96RI1 CHEMBL2047 Nuclear receptor 0.0
 6 / 0     
Serotonin 5a (5-HT5a) receptor HTR5A P47898 CHEMBL3426 Family A G protein-coupled receptor 0.0
 14 / 0     
Calcium-activated potassium channel subunit alpha-1 KCNMA1 Q12791 CHEMBL4304 Voltage-gated ion channel 0.0
 10 / 0     
Phosphodiesterase 10A (by homology) PDE10A Q9Y233 CHEMBL4409 Phosphodiesterase 0.0
 53 / 0     
Glutaminyl-peptide cyclotransferase QPCT Q16769 CHEMBL4508 Enzyme 0.0
 44 / 0     
Aldose reductase (by homology) AKR1B1 P15121 CHEMBL1900 Enzyme 0.0
 6 / 0     
c-Jun N-terminal kinase 3 MAPK10 P53779 CHEMBL2637 Kinase 0.0
 23 / 0     
Cytochrome P450 2C19 CYP2C19 P33261 CHEMBL3622 Cytochrome P450 0.0
 3 / 0     
Phosphodiesterase 5A PDE5A O76074 CHEMBL1827 Phosphodiesterase 0.0
 45 / 0     
Isocitrate dehydrogenase [NADP] cytoplasmic IDH1 O75874 CHEMBL2007625 Enzyme 0.0
 10 / 0     
MAP kinase p38 alpha MAPK14 Q16539 CHEMBL260 Kinase 0.0
 33 / 0     
TGF-beta receptor type I TGFBR1 P36897 CHEMBL4439 Kinase 0.0
 12 / 0     
Gamma-secretase PSEN2 PSENEN NCSTN APH1A PSEN1 APH1B P49810 Q9NZ42 Q92542 Q96BI3 P49768 Q8WW43 CHEMBL2094135 Protease 0.0
 24 / 0     
Hepatocyte growth factor receptor MET P08581 CHEMBL3717 Kinase 0.0
 38 / 0     
p53-binding protein Mdm-2 MDM2 Q00987 CHEMBL5023 Other nuclear protein 0.0
 20 / 0     
Thromboxane-A synthase TBXAS1 P24557 CHEMBL1835 Cytochrome P450 0.0
 2 / 0     
3-phosphoinositide dependent protein kinase-1 PDPK1 O15530 CHEMBL2534 Kinase 0.0
 9 / 0     
Phosphodiesterase 2A PDE2A O00408 CHEMBL2652 Phosphodiesterase 0.0
 26 / 0     
Voltage-gated potassium channel subunit Kv1.5 KCNA5 P22460 CHEMBL4306 Voltage-gated ion channel 0.0
 15 / 0     
Prostaglandin E synthase PTGES O14684 CHEMBL5658 Enzyme 0.0
 18 / 0     
Toll-like receptor 8 TLR8 Q9NR97 CHEMBL5805 Toll-like and Il-1 receptors 0.0
 1 / 0     
Cannabinoid receptor 1 CNR1 P21554 CHEMBL218 Family A G protein-coupled receptor 0.0
 123 / 0     
Muscarinic acetylcholine receptor M5 CHRM5 P08912 CHEMBL2035 Family A G protein-coupled receptor 0.0
 2 / 0     
Muscarinic acetylcholine receptor M2 CHRM2 P08172 CHEMBL211 Family A G protein-coupled receptor 0.0
 3 / 0     
Muscarinic acetylcholine receptor M1 CHRM1 P11229 CHEMBL216 Family A G protein-coupled receptor 0.0
 9 / 0     
Interleukin-8 receptor B CXCR2 P25025 CHEMBL2434 Family A G protein-coupled receptor 0.0
 38 / 0     
Cytochrome P450 17A1 CYP17A1 P05093 CHEMBL3522 Cytochrome P450 0.0
 5 / 0     
Arachidonate 5-lipoxygenase ALOX5 P09917 CHEMBL215 Oxidoreductase 0.0
 61 / 0     
Nischarin NISCH Q9Y2I1 CHEMBL3923 Other cytosolic protein 0.0
 45 / 0     
C-X-C chemokine receptor type 3 CXCR3 P49682 CHEMBL4441 Family A G protein-coupled receptor 0.0
 27 / 0     
Cytochrome P450 19A1 CYP19A1 P11511 CHEMBL1978 Cytochrome P450 0.0
 13 / 0     
Sodium/hydrogen exchanger 1 SLC9A1 P19634 CHEMBL2781 Electrochemical transporter 0.0
 9 / 0     
Beta-secretase 1 BACE1 P56817 CHEMBL4822 Protease 0.0
 229 / 0     
Cholecystokinin A receptor CCKAR P32238 CHEMBL1901 Family A G protein-coupled receptor 0.0
 3 / 0     
Cyclooxygenase-1 PTGS1 P23219 CHEMBL221 Oxidoreductase 0.0
 14 / 0     
Cyclooxygenase-2 PTGS2 P35354 CHEMBL230 Oxidoreductase 0.0
 47 / 0     
Histamine H1 receptor HRH1 P35367 CHEMBL231 Family A G protein-coupled receptor 0.0
 3 / 0     
Liver glycogen phosphorylase PYGL P06737 CHEMBL2568 Enzyme 0.0
 6 / 0     
Carbonic anhydrase I CA1 P00915 CHEMBL261 Lyase 0.0
 56 / 0     
Cholecystokinin B receptor CCKBR P32239 CHEMBL298 Family A G protein-coupled receptor 0.0
 70 / 0     
Carbonic anhydrase IX CA9 Q16790 CHEMBL3594 Lyase 0.0
 42 / 0     
Nitric oxide synthase, inducible NOS2 P35228 CHEMBL4481 Enzyme 0.0
 33 / 0     
Histone deacetylase 3/Nuclear receptor corepressor 2 (HDAC3/NCoR2) NCOR2 HDAC3 Q9Y618 O15379 CHEMBL2111363 Eraser 0.0
 0 / 5     
Muscarinic acetylcholine receptor M3 CHRM3 P20309 CHEMBL245 Family A G protein-coupled receptor 0.0
 17 / 0     
11-beta-hydroxysteroid dehydrogenase 2 HSD11B2 P80365 CHEMBL3746 Enzyme 0.0
 2 / 0     
Voltage-gated potassium channel subunit Kv1.3 KCNA3 P22001 CHEMBL4633 Voltage-gated ion channel 0.0
 4 / 0     
P2X purinoceptor 7 P2RX7 Q99572 CHEMBL4805 Ligand-gated ion channel 0.0
 46 / 0     
Serotonin 2b (5-HT2b) receptor HTR2B P41595 CHEMBL1833 Family A G protein-coupled receptor 0.0
 17 / 0     
Thymidylate synthase TYMS P04818 CHEMBL1952 Transferase 0.0
 26 / 0     
HERG KCNH2 Q12809 CHEMBL240 Voltage-gated ion channel 0.0
 13 / 0     
Transitional endoplasmic reticulum ATPase VCP P55072 CHEMBL1075145 Primary active transporter 0.0
 3 / 0     
Glutamate NMDA receptor; GRIN1/GRIN2B GRIN1 GRIN2B Q05586 Q13224 CHEMBL1907603 Ligand-gated ion channel 0.0
 9 / 0     
Cyclin-dependent kinase 2/cyclin A CDK2 CCNA1 CCNA2 P24941 P78396 P20248 CHEMBL2094128 Other cytosolic protein 0.0
 11 / 0     
Cytochrome P450 26A1 CYP26A1 O43174 CHEMBL5141 Cytochrome P450 0.0
 4 / 0     
Serotonin 1b (5-HT1b) receptor HTR1B P28222 CHEMBL1898 Family A G protein-coupled receptor 0.0
 8 / 0     
Histamine H2 receptor HRH2 P25021 CHEMBL1941 Family A G protein-coupled receptor 0.0
 3 / 0     
Serotonin 1d (5-HT1d) receptor HTR1D P28221 CHEMBL1983 Family A G protein-coupled receptor 0.0
 12 / 0     
Serotonin transporter (by homology) SLC6A4 P31645 CHEMBL228 Electrochemical transporter 0.0
 6 / 0     
Cyclin-dependent kinase 2 CDK2 P24941 CHEMBL301 Kinase 0.0
 20 / 0     
Purine nucleoside phosphorylase PNP P00491 CHEMBL4338 Enzyme 0.0
 6 / 0     
Serotonin 1a (5-HT1a) receptor HTR1A P08908 CHEMBL214 Family A G protein-coupled receptor 0.0
 28 / 0     
Cannabinoid receptor 2 CNR2 P34972 CHEMBL253 Family A G protein-coupled receptor 0.0
 72 / 0     
Serine/threonine-protein kinase PLK1 PLK1 P53350 CHEMBL3024 Kinase 0.0
 18 / 0     
Pantothenate kinase 3 PANK3 Q9H999 CHEMBL3407328 Enzyme 0.0
 2 / 0     
Serine/threonine-protein kinase PLK2 PLK2 Q9NYY3 CHEMBL5938 Kinase 0.0
 7 / 0     
Cyclin-dependent kinase 1/cyclin B1 CDK1 CCNB1 P06493 P14635 CHEMBL1907602 Other cytosolic protein 0.0
 2 / 0     

*Probability for the query molecule - assumed as bioactive - to have this protein as target.