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Swiss Institute of Bioinformatics
SwissTargetPrediction
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Query Molecule
Target Classes
Top 15
Top 25
Top 50
All
Export results:
Target | Common name | Uniprot ID | ChEMBL ID | Target Class | Probability* | Known actives (3D/2D) |
---|---|---|---|---|---|---|
Dopamine transporter | SLC6A3 | Q01959 | CHEMBL238 | Electrochemical transporter | 0.048952897826 |
11 /
1   |
11-beta-hydroxysteroid dehydrogenase 1 | HSD11B1 | P28845 | CHEMBL4235 | Enzyme | 0.048952897826 |
63 /
28   |
Histone deacetylase 6 | HDAC6 | Q9UBN7 | CHEMBL1865 | Eraser | 0.048952897826 |
25 /
0   |
Glutaminyl-peptide cyclotransferase-like protein | QPCTL | Q9NXS2 | CHEMBL3638349 | Transferase | 0.048952897826 |
6 /
0   |
Adenosine A2b receptor | ADORA2B | P29275 | CHEMBL255 | Family A G protein-coupled receptor | 0.048952897826 |
6 /
0   |
Vascular endothelial growth factor receptor 1 | FLT1 | P17948 | CHEMBL1868 | Kinase | 0.048952897826 |
16 /
0   |
Vascular endothelial growth factor receptor 2 | KDR | P35968 | CHEMBL279 | Kinase | 0.048952897826 |
62 /
0   |
Histone deacetylase 1 | HDAC1 | Q13547 | CHEMBL325 | Eraser | 0.048952897826 |
31 /
4   |
Adenosine A3 receptor | ADORA3 | P0DMS8 | CHEMBL256 | Family A G protein-coupled receptor | 0.048952897826 |
16 /
0   |
Alpha-1d adrenergic receptor | ADRA1D | P25100 | CHEMBL223 | Family A G protein-coupled receptor | 0.048952897826 |
26 /
0   |
Alpha-1b adrenergic receptor | ADRA1B | P35368 | CHEMBL232 | Family A G protein-coupled receptor | 0.048952897826 |
24 /
0   |
Metabotropic glutamate receptor 5 | GRM5 | P41594 | CHEMBL3227 | Family C G protein-coupled receptor | 0.048952897826 |
50 /
0   |
Metabotropic glutamate receptor 1 | GRM1 | Q13255 | CHEMBL3772 | Family C G protein-coupled receptor | 0.048952897826 |
4 /
0   |
Metabotropic glutamate receptor 4 | GRM4 | Q14833 | CHEMBL2736 | Family C G protein-coupled receptor | 0.048952897826 |
2 /
0   |
Tyrosine-protein kinase JAK3 | JAK3 | P52333 | CHEMBL2148 | Kinase | 0.0 |
108 /
0   |
Tyrosine-protein kinase JAK1 | JAK1 | P23458 | CHEMBL2835 | Kinase | 0.0 |
49 /
0   |
Tyrosine-protein kinase JAK2 | JAK2 | O60674 | CHEMBL2971 | Kinase | 0.0 |
86 /
0   |
c-Jun N-terminal kinase 1 | MAPK8 | P45983 | CHEMBL2276 | Kinase | 0.0 |
24 /
0   |
Adenosine A2a receptor | ADORA2A | P29274 | CHEMBL251 | Family A G protein-coupled receptor | 0.0 |
32 /
0   |
Serotonin 2a (5-HT2a) receptor (by homology) | HTR2A | P28223 | CHEMBL224 | Family A G protein-coupled receptor | 0.0 |
21 /
0   |
Trace amine-associated receptor 1 (by homology) | TAAR1 | Q96RJ0 | CHEMBL5857 | Family A G protein-coupled receptor | 0.0 |
35 /
0   |
Epidermal growth factor receptor erbB1 | EGFR | P00533 | CHEMBL203 | Kinase | 0.0 |
98 /
0   |
Prolyl endopeptidase | PREP | P48147 | CHEMBL3202 | Protease | 0.0 |
5 /
0   |
Fibroblast activation protein alpha (by homology) | FAP | Q12884 | CHEMBL4683 | Protease | 0.0 |
9 /
0   |
G-protein coupled bile acid receptor 1 | GPBAR1 | Q8TDU6 | CHEMBL5409 | Family A G protein-coupled receptor | 0.0 |
16 /
0   |
Amine oxidase, copper containing | AOC3 | Q16853 | CHEMBL3437 | Enzyme | 0.0 |
6 /
0   |
Androgen Receptor (by homology) | AR | P10275 | CHEMBL1871 | Nuclear receptor | 0.0 |
13 /
0   |
C-C chemokine receptor type 5 | CCR5 | P51681 | CHEMBL274 | Family A G protein-coupled receptor | 0.0 |
11 /
0   |
Mineralocorticoid receptor | NR3C2 | P08235 | CHEMBL1994 | Nuclear receptor | 0.0 |
36 /
0   |
Dihydrofolate reductase | DHFR | P00374 | CHEMBL202 | Oxidoreductase | 0.0 |
21 /
0   |
Serine/threonine-protein kinase Aurora-B | AURKB | Q96GD4 | CHEMBL2185 | Kinase | 0.0 |
4 /
0   |
Orexin receptor 2 | HCRTR2 | O43614 | CHEMBL4792 | Family A G protein-coupled receptor | 0.0 |
45 /
0   |
Orexin receptor 1 | HCRTR1 | O43613 | CHEMBL5113 | Family A G protein-coupled receptor | 0.0 |
40 /
0   |
Sigma opioid receptor | SIGMAR1 | Q99720 | CHEMBL287 | Membrane receptor | 0.0 |
14 /
0   |
Bile acid receptor FXR | NR1H4 | Q96RI1 | CHEMBL2047 | Nuclear receptor | 0.0 |
6 /
0   |
Serotonin 5a (5-HT5a) receptor | HTR5A | P47898 | CHEMBL3426 | Family A G protein-coupled receptor | 0.0 |
14 /
0   |
Calcium-activated potassium channel subunit alpha-1 | KCNMA1 | Q12791 | CHEMBL4304 | Voltage-gated ion channel | 0.0 |
10 /
0   |
Phosphodiesterase 10A (by homology) | PDE10A | Q9Y233 | CHEMBL4409 | Phosphodiesterase | 0.0 |
53 /
0   |
Glutaminyl-peptide cyclotransferase | QPCT | Q16769 | CHEMBL4508 | Enzyme | 0.0 |
44 /
0   |
Aldose reductase (by homology) | AKR1B1 | P15121 | CHEMBL1900 | Enzyme | 0.0 |
6 /
0   |
c-Jun N-terminal kinase 3 | MAPK10 | P53779 | CHEMBL2637 | Kinase | 0.0 |
23 /
0   |
Cytochrome P450 2C19 | CYP2C19 | P33261 | CHEMBL3622 | Cytochrome P450 | 0.0 |
3 /
0   |
Phosphodiesterase 5A | PDE5A | O76074 | CHEMBL1827 | Phosphodiesterase | 0.0 |
45 /
0   |
Isocitrate dehydrogenase [NADP] cytoplasmic | IDH1 | O75874 | CHEMBL2007625 | Enzyme | 0.0 |
10 /
0   |
MAP kinase p38 alpha | MAPK14 | Q16539 | CHEMBL260 | Kinase | 0.0 |
33 /
0   |
TGF-beta receptor type I | TGFBR1 | P36897 | CHEMBL4439 | Kinase | 0.0 |
12 /
0   |
Gamma-secretase | PSEN2 PSENEN NCSTN APH1A PSEN1 APH1B | P49810 Q9NZ42 Q92542 Q96BI3 P49768 Q8WW43 | CHEMBL2094135 | Protease | 0.0 |
24 /
0   |
Hepatocyte growth factor receptor | MET | P08581 | CHEMBL3717 | Kinase | 0.0 |
38 /
0   |
p53-binding protein Mdm-2 | MDM2 | Q00987 | CHEMBL5023 | Other nuclear protein | 0.0 |
20 /
0   |
Thromboxane-A synthase | TBXAS1 | P24557 | CHEMBL1835 | Cytochrome P450 | 0.0 |
2 /
0   |
3-phosphoinositide dependent protein kinase-1 | PDPK1 | O15530 | CHEMBL2534 | Kinase | 0.0 |
9 /
0   |
Phosphodiesterase 2A | PDE2A | O00408 | CHEMBL2652 | Phosphodiesterase | 0.0 |
26 /
0   |
Voltage-gated potassium channel subunit Kv1.5 | KCNA5 | P22460 | CHEMBL4306 | Voltage-gated ion channel | 0.0 |
15 /
0   |
Prostaglandin E synthase | PTGES | O14684 | CHEMBL5658 | Enzyme | 0.0 |
18 /
0   |
Toll-like receptor 8 | TLR8 | Q9NR97 | CHEMBL5805 | Toll-like and Il-1 receptors | 0.0 |
1 /
0   |
Cannabinoid receptor 1 | CNR1 | P21554 | CHEMBL218 | Family A G protein-coupled receptor | 0.0 |
123 /
0   |
Muscarinic acetylcholine receptor M5 | CHRM5 | P08912 | CHEMBL2035 | Family A G protein-coupled receptor | 0.0 |
2 /
0   |
Muscarinic acetylcholine receptor M2 | CHRM2 | P08172 | CHEMBL211 | Family A G protein-coupled receptor | 0.0 |
3 /
0   |
Muscarinic acetylcholine receptor M1 | CHRM1 | P11229 | CHEMBL216 | Family A G protein-coupled receptor | 0.0 |
9 /
0   |
Interleukin-8 receptor B | CXCR2 | P25025 | CHEMBL2434 | Family A G protein-coupled receptor | 0.0 |
38 /
0   |
Cytochrome P450 17A1 | CYP17A1 | P05093 | CHEMBL3522 | Cytochrome P450 | 0.0 |
5 /
0   |
Arachidonate 5-lipoxygenase | ALOX5 | P09917 | CHEMBL215 | Oxidoreductase | 0.0 |
61 /
0   |
Nischarin | NISCH | Q9Y2I1 | CHEMBL3923 | Other cytosolic protein | 0.0 |
45 /
0   |
C-X-C chemokine receptor type 3 | CXCR3 | P49682 | CHEMBL4441 | Family A G protein-coupled receptor | 0.0 |
27 /
0   |
Cytochrome P450 19A1 | CYP19A1 | P11511 | CHEMBL1978 | Cytochrome P450 | 0.0 |
13 /
0   |
Sodium/hydrogen exchanger 1 | SLC9A1 | P19634 | CHEMBL2781 | Electrochemical transporter | 0.0 |
9 /
0   |
Beta-secretase 1 | BACE1 | P56817 | CHEMBL4822 | Protease | 0.0 |
229 /
0   |
Cholecystokinin A receptor | CCKAR | P32238 | CHEMBL1901 | Family A G protein-coupled receptor | 0.0 |
3 /
0   |
Cyclooxygenase-1 | PTGS1 | P23219 | CHEMBL221 | Oxidoreductase | 0.0 |
14 /
0   |
Cyclooxygenase-2 | PTGS2 | P35354 | CHEMBL230 | Oxidoreductase | 0.0 |
47 /
0   |
Histamine H1 receptor | HRH1 | P35367 | CHEMBL231 | Family A G protein-coupled receptor | 0.0 |
3 /
0   |
Liver glycogen phosphorylase | PYGL | P06737 | CHEMBL2568 | Enzyme | 0.0 |
6 /
0   |
Carbonic anhydrase I | CA1 | P00915 | CHEMBL261 | Lyase | 0.0 |
56 /
0   |
Cholecystokinin B receptor | CCKBR | P32239 | CHEMBL298 | Family A G protein-coupled receptor | 0.0 |
70 /
0   |
Carbonic anhydrase IX | CA9 | Q16790 | CHEMBL3594 | Lyase | 0.0 |
42 /
0   |
Nitric oxide synthase, inducible | NOS2 | P35228 | CHEMBL4481 | Enzyme | 0.0 |
33 /
0   |
Histone deacetylase 3/Nuclear receptor corepressor 2 (HDAC3/NCoR2) | NCOR2 HDAC3 | Q9Y618 O15379 | CHEMBL2111363 | Eraser | 0.0 |
0 /
5   |
Muscarinic acetylcholine receptor M3 | CHRM3 | P20309 | CHEMBL245 | Family A G protein-coupled receptor | 0.0 |
17 /
0   |
11-beta-hydroxysteroid dehydrogenase 2 | HSD11B2 | P80365 | CHEMBL3746 | Enzyme | 0.0 |
2 /
0   |
Voltage-gated potassium channel subunit Kv1.3 | KCNA3 | P22001 | CHEMBL4633 | Voltage-gated ion channel | 0.0 |
4 /
0   |
P2X purinoceptor 7 | P2RX7 | Q99572 | CHEMBL4805 | Ligand-gated ion channel | 0.0 |
46 /
0   |
Serotonin 2b (5-HT2b) receptor | HTR2B | P41595 | CHEMBL1833 | Family A G protein-coupled receptor | 0.0 |
17 /
0   |
Thymidylate synthase | TYMS | P04818 | CHEMBL1952 | Transferase | 0.0 |
26 /
0   |
HERG | KCNH2 | Q12809 | CHEMBL240 | Voltage-gated ion channel | 0.0 |
13 /
0   |
Transitional endoplasmic reticulum ATPase | VCP | P55072 | CHEMBL1075145 | Primary active transporter | 0.0 |
3 /
0   |
Glutamate NMDA receptor; GRIN1/GRIN2B | GRIN1 GRIN2B | Q05586 Q13224 | CHEMBL1907603 | Ligand-gated ion channel | 0.0 |
9 /
0   |
Cyclin-dependent kinase 2/cyclin A | CDK2 CCNA1 CCNA2 | P24941 P78396 P20248 | CHEMBL2094128 | Other cytosolic protein | 0.0 |
11 /
0   |
Cytochrome P450 26A1 | CYP26A1 | O43174 | CHEMBL5141 | Cytochrome P450 | 0.0 |
4 /
0   |
Serotonin 1b (5-HT1b) receptor | HTR1B | P28222 | CHEMBL1898 | Family A G protein-coupled receptor | 0.0 |
8 /
0   |
Histamine H2 receptor | HRH2 | P25021 | CHEMBL1941 | Family A G protein-coupled receptor | 0.0 |
3 /
0   |
Serotonin 1d (5-HT1d) receptor | HTR1D | P28221 | CHEMBL1983 | Family A G protein-coupled receptor | 0.0 |
12 /
0   |
Serotonin transporter (by homology) | SLC6A4 | P31645 | CHEMBL228 | Electrochemical transporter | 0.0 |
6 /
0   |
Cyclin-dependent kinase 2 | CDK2 | P24941 | CHEMBL301 | Kinase | 0.0 |
20 /
0   |
Purine nucleoside phosphorylase | PNP | P00491 | CHEMBL4338 | Enzyme | 0.0 |
6 /
0   |
Serotonin 1a (5-HT1a) receptor | HTR1A | P08908 | CHEMBL214 | Family A G protein-coupled receptor | 0.0 |
28 /
0   |
Cannabinoid receptor 2 | CNR2 | P34972 | CHEMBL253 | Family A G protein-coupled receptor | 0.0 |
72 /
0   |
Serine/threonine-protein kinase PLK1 | PLK1 | P53350 | CHEMBL3024 | Kinase | 0.0 |
18 /
0   |
Pantothenate kinase 3 | PANK3 | Q9H999 | CHEMBL3407328 | Enzyme | 0.0 |
2 /
0   |
Serine/threonine-protein kinase PLK2 | PLK2 | Q9NYY3 | CHEMBL5938 | Kinase | 0.0 |
7 /
0   |
Cyclin-dependent kinase 1/cyclin B1 | CDK1 CCNB1 | P06493 P14635 | CHEMBL1907602 | Other cytosolic protein | 0.0 |
2 /
0   |
*Probability for the query molecule - assumed as bioactive - to have this protein as target.