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Swiss Institute of Bioinformatics
SwissTargetPrediction
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Query Molecule
Target Classes
Top 15
Top 25
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All
Export results:
Target | Common name | Uniprot ID | ChEMBL ID | Target Class | Probability* | Known actives (3D/2D) |
---|---|---|---|---|---|---|
Glutamate NMDA receptor; GRIN1/GRIN2B | GRIN1 GRIN2B | Q05586 Q13224 | CHEMBL1907603 | Ligand-gated ion channel | 0.677770377193 |
1 /
9   |
Glutamate NMDA receptor; GRIN1/GRIN2A | GRIN2A GRIN1 | Q12879 Q05586 | CHEMBL1907604 | Ligand-gated ion channel | 0.677770377193 |
1 /
14   |
Butyrylcholinesterase (by homology) | BCHE | P06276 | CHEMBL1914 | Hydrolase | 0.677770377193 |
9 /
72   |
Lysosomal Pro-X carboxypeptidase | PRCP | P42785 | CHEMBL2335 | Protease | 0.677770377193 |
14 /
42   |
Sigma opioid receptor | SIGMAR1 | Q99720 | CHEMBL287 | Membrane receptor | 0.677770377193 |
236 /
879   |
Serotonin transporter (by homology) | SLC6A4 | P31645 | CHEMBL228 | Electrochemical transporter | 0.42597438872 |
212 /
1136   |
Dopamine transporter (by homology) | SLC6A3 | Q01959 | CHEMBL238 | Electrochemical transporter | 0.42597438872 |
238 /
1272   |
Mu opioid receptor | OPRM1 | P35372 | CHEMBL233 | Family A G protein-coupled receptor | 0.284705359937 |
17 /
953   |
Dopamine D2 receptor | DRD2 | P14416 | CHEMBL217 | Family A G protein-coupled receptor | 0.221938203373 |
147 /
622   |
Serotonin 2a (5-HT2a) receptor | HTR2A | P28223 | CHEMBL224 | Family A G protein-coupled receptor | 0.174862804543 |
66 /
192   |
Kappa Opioid receptor | OPRK1 | P41145 | CHEMBL237 | Family A G protein-coupled receptor | 0.174862804543 |
15 /
570   |
Acetylcholinesterase | ACHE | P22303 | CHEMBL220 | Hydrolase | 0.151315356696 |
7 /
295   |
Nociceptin receptor | OPRL1 | P41146 | CHEMBL2014 | Family A G protein-coupled receptor | 0.151315356696 |
0 /
336   |
Synaptic vesicular amine transporter (by homology) | SLC18A2 | Q05940 | CHEMBL1893 | Electrochemical transporter | 0.143473412261 |
26 /
173   |
Muscarinic acetylcholine receptor M1 | CHRM1 | P11229 | CHEMBL216 | Family A G protein-coupled receptor | 0.143473412261 |
23 /
119   |
Delta opioid receptor | OPRD1 | P41143 | CHEMBL236 | Family A G protein-coupled receptor | 0.135616202575 |
10 /
603   |
Muscarinic acetylcholine receptor M4 | CHRM4 | P08173 | CHEMBL1821 | Family A G protein-coupled receptor | 0.135616202575 |
18 /
46   |
Muscarinic acetylcholine receptor M5 | CHRM5 | P08912 | CHEMBL2035 | Family A G protein-coupled receptor | 0.135616202575 |
19 /
37   |
Muscarinic acetylcholine receptor M2 | CHRM2 | P08172 | CHEMBL211 | Family A G protein-coupled receptor | 0.135616202575 |
27 /
173   |
Histamine H3 receptor | HRH3 | Q9Y5N1 | CHEMBL264 | Family A G protein-coupled receptor | 0.135616202575 |
30 /
267   |
Alpha-1b adrenergic receptor | ADRA1B | P35368 | CHEMBL232 | Family A G protein-coupled receptor | 0.127750341333 |
5 /
14   |
Norepinephrine transporter | SLC6A2 | P23975 | CHEMBL222 | Electrochemical transporter | 0.127750341333 |
150 /
567   |
Neuronal acetylcholine receptor; alpha3/beta4 | CHRNA3 CHRNB4 | P32297 P30926 | CHEMBL1907594 | Ligand-gated ion channel | 0.119895126898 |
6 /
16   |
Histamine H2 receptor | HRH2 | P25021 | CHEMBL1941 | Family A G protein-coupled receptor | 0.119895126898 |
14 /
15   |
C-C chemokine receptor type 3 | CCR3 | P51677 | CHEMBL3473 | Family A G protein-coupled receptor | 0.119895126898 |
2 /
71   |
HERG | KCNH2 | Q12809 | CHEMBL240 | Voltage-gated ion channel | 0.119895126898 |
32 /
219   |
Serotonin 2b (5-HT2b) receptor | HTR2B | P41595 | CHEMBL1833 | Family A G protein-coupled receptor | 0.112041901328 |
22 /
33   |
Voltage-gated T-type calcium channel alpha-1G subunit | CACNA1G | O43497 | CHEMBL4641 | Voltage-gated ion channel | 0.112041901328 |
0 /
27   |
Glutamate [NMDA] receptor subunit epsilon 2 | GRIN2B | Q13224 | CHEMBL1904 | Ligand-gated ion channel | 0.112041901328 |
4 /
15   |
Serotonin 1a (5-HT1a) receptor | HTR1A | P08908 | CHEMBL214 | Family A G protein-coupled receptor | 0.112041901328 |
22 /
133   |
Histamine H1 receptor | HRH1 | P35367 | CHEMBL231 | Family A G protein-coupled receptor | 0.112041901328 |
25 /
47   |
Glycine transporter 1 | SLC6A9 | P48067 | CHEMBL2337 | Electrochemical transporter | 0.112041901328 |
0 /
51   |
C-X-C chemokine receptor type 3 | CXCR3 | P49682 | CHEMBL4441 | Family A G protein-coupled receptor | 0.112041901328 |
14 /
85   |
Muscarinic acetylcholine receptor M3 | CHRM3 | P20309 | CHEMBL245 | Family A G protein-coupled receptor | 0.112041901328 |
14 /
108   |
Dopamine D4 receptor | DRD4 | P21917 | CHEMBL219 | Family A G protein-coupled receptor | 0.112041901328 |
22 /
133   |
Sphingosine kinase 2 | SPHK2 | Q9NRA0 | CHEMBL3023 | Enzyme | 0.112041901328 |
0 /
16   |
Lanosterol synthase | LSS | P48449 | CHEMBL3593 | Enzyme | 0.112041901328 |
0 /
8   |
Dopamine D3 receptor | DRD3 | P35462 | CHEMBL234 | Family A G protein-coupled receptor | 0.112041901328 |
77 /
229   |
Serotonin 7 (5-HT7) receptor | HTR7 | P34969 | CHEMBL3155 | Family A G protein-coupled receptor | 0.112041901328 |
18 /
40   |
Cathepsin S | CTSS | P25774 | CHEMBL2954 | Protease | 0.112041901328 |
0 /
16   |
Dipeptidyl peptidase IV | DPP4 | P27487 | CHEMBL284 | Protease | 0.112041901328 |
0 /
132   |
11-beta-hydroxysteroid dehydrogenase 1 | HSD11B1 | P28845 | CHEMBL4235 | Enzyme | 0.112041901328 |
0 /
252   |
Voltage-gated potassium channel subunit Kv1.5 | KCNA5 | P22460 | CHEMBL4306 | Voltage-gated ion channel | 0.112041901328 |
0 /
4   |
Lethal(3)malignant brain tumor-like protein 3 | L3MBTL3 | Q96JM7 | CHEMBL1287623 | Reader | 0.112041901328 |
0 /
52   |
Nuclear receptor subfamily 1 group D member 2 | NR1D2 | Q14995 | CHEMBL1961784 | Nuclear receptor | 0.112041901328 |
0 /
1   |
Alpha-2b adrenergic receptor | ADRA2B | P18089 | CHEMBL1942 | Family A G protein-coupled receptor | 0.112041901328 |
16 /
13   |
Alpha-1a adrenergic receptor | ADRA1A | P35348 | CHEMBL229 | Family A G protein-coupled receptor | 0.112041901328 |
16 /
42   |
MAP kinase p38 alpha | MAPK14 | Q16539 | CHEMBL260 | Kinase | 0.112041901328 |
0 /
6   |
Sphingosine 1-phosphate receptor Edg-5 | S1PR2 | O95136 | CHEMBL2955 | Family A G protein-coupled receptor | 0.112041901328 |
0 /
16   |
Cytochrome P450 2C9 | CYP2C9 | P11712 | CHEMBL3397 | Cytochrome P450 | 0.112041901328 |
0 /
5   |
Sphingosine 1-phosphate receptor Edg-3 | S1PR3 | Q99500 | CHEMBL3892 | Family A G protein-coupled receptor | 0.112041901328 |
0 /
21   |
Sphingosine 1-phosphate receptor Edg-1 | S1PR1 | P21453 | CHEMBL4333 | Family A G protein-coupled receptor | 0.112041901328 |
0 /
24   |
Adrenergic receptor alpha-2 | ADRA2C | P18825 | CHEMBL1916 | Family A G protein-coupled receptor | 0.112041901328 |
17 /
23   |
C-C chemokine receptor type 5 | CCR5 | P51681 | CHEMBL274 | Family A G protein-coupled receptor | 0.112041901328 |
0 /
154   |
Alpha-1d adrenergic receptor | ADRA1D | P25100 | CHEMBL223 | Family A G protein-coupled receptor | 0.112041901328 |
9 /
11   |
Neurokinin 1 receptor | TACR1 | P25103 | CHEMBL249 | Family A G protein-coupled receptor | 0.112041901328 |
5 /
332   |
Squalene synthetase (by homology) | FDFT1 | P37268 | CHEMBL3338 | Enzyme | 0.112041901328 |
0 /
15   |
Neuronal acetylcholine receptor; alpha4/beta2 | CHRNA4 CHRNB2 | P43681 P17787 | CHEMBL1907589 | Ligand-gated ion channel | 0.112041901328 |
12 /
38   |
Arachidonate 5-lipoxygenase | ALOX5 | P09917 | CHEMBL215 | Oxidoreductase | 0.112041901328 |
0 /
9   |
Sphingosine 1-phosphate receptor Edg-6 | S1PR4 | O95977 | CHEMBL3230 | Family A G protein-coupled receptor | 0.112041901328 |
0 /
15   |
GABA transporter 2 (by homology) | SLC6A13 | Q9NSD5 | CHEMBL4535 | Electrochemical transporter | 0.112041901328 |
0 /
3   |
Melanocortin receptor 4 | MC4R | P32245 | CHEMBL259 | Family A G protein-coupled receptor | 0.112041901328 |
0 /
112   |
Gamma-secretase | PSEN2 PSENEN NCSTN APH1A PSEN1 APH1B | P49810 Q9NZ42 Q92542 Q96BI3 P49768 Q8WW43 | CHEMBL2094135 | Protease | 0.112041901328 |
0 /
15   |
Anti-estrogen binding site (AEBS) | EBP | Q15125 | CHEMBL4931 | Enzyme | 0.0 |
1 /
15   |
Serotonin 5a (5-HT5a) receptor | HTR5A | P47898 | CHEMBL3426 | Family A G protein-coupled receptor | 0.0 |
7 /
20   |
Vesicular acetylcholine transporter | SLC18A3 | Q16572 | CHEMBL4767 | Electrochemical transporter | 0.0 |
1 /
97   |
Dipeptidyl peptidase I | CTSC | P53634 | CHEMBL2252 | Protease | 0.0 |
0 /
3   |
Cathepsin K | CTSK | P43235 | CHEMBL268 | Protease | 0.0 |
0 /
27   |
Cathepsin L | CTSL | P07711 | CHEMBL3837 | Protease | 0.0 |
0 /
17   |
Cathepsin (B and K) | CTSB | P07858 | CHEMBL4072 | Protease | 0.0 |
0 /
13   |
Protein arginine N-methyltransferase 6 | PRMT6 | Q96LA8 | CHEMBL1275221 | Writer | 0.0 |
0 /
1   |
Protein arginine N-methyltransferase 8 | PRMT8 | Q9NR22 | CHEMBL3108648 | Writer | 0.0 |
0 /
1   |
Histone-arginine methyltransferase CARM1 | CARM1 | Q86X55 | CHEMBL5406 | Writer | 0.0 |
0 /
1   |
Malonyl-CoA decarboxylase | MLYCD | O95822 | CHEMBL4698 | Enzyme | 0.0 |
0 /
25   |
Lysine-specific histone demethylase 1 | KDM1A | O60341 | CHEMBL6136 | Eraser | 0.0 |
2 /
62   |
Epoxide hydratase | EPHX2 | P34913 | CHEMBL2409 | Protease | 0.0 |
0 /
69   |
Cytochrome P450 2C19 | CYP2C19 | P33261 | CHEMBL3622 | Cytochrome P450 | 0.0 |
2 /
6   |
Nitric oxide synthase, inducible | NOS2 | P35228 | CHEMBL4481 | Enzyme | 0.0 |
0 /
27   |
Serotonin 2c (5-HT2c) receptor | HTR2C | P28335 | CHEMBL225 | Family A G protein-coupled receptor | 0.0 |
37 /
51   |
Carbonic anhydrase II | CA2 | P00918 | CHEMBL205 | Lyase | 0.0 |
0 /
13   |
Carbonic anhydrase XII | CA12 | O43570 | CHEMBL3242 | Lyase | 0.0 |
0 /
9   |
Carbonic anhydrase IX | CA9 | Q16790 | CHEMBL3594 | Lyase | 0.0 |
0 /
8   |
P2X purinoceptor 7 | P2RX7 | Q99572 | CHEMBL4805 | Ligand-gated ion channel | 0.0 |
1 /
21   |
Sphingosine 1-phosphate receptor Edg-8 | S1PR5 | Q9H228 | CHEMBL2274 | Family A G protein-coupled receptor | 0.0 |
0 /
17   |
Neuropeptide Y receptor type 1 | NPY1R | P25929 | CHEMBL4777 | Family A G protein-coupled receptor | 0.0 |
0 /
33   |
N-acylsphingosine-amidohydrolase | NAAA | Q02083 | CHEMBL4349 | Enzyme | 0.0 |
0 /
3   |
Histone deacetylase 6 | HDAC6 | Q9UBN7 | CHEMBL1865 | Eraser | 0.0 |
0 /
41   |
MBT domain-containing protein 1 | MBTD1 | Q05BQ5 | CHEMBL1287625 | Reader | 0.0 |
0 /
12   |
Sphingosine kinase 1 | SPHK1 | Q9NYA1 | CHEMBL4394 | Enzyme | 0.0 |
0 /
16   |
Thyroid hormone receptor beta-1 | THRB | P10828 | CHEMBL1947 | Nuclear receptor | 0.0 |
0 /
9   |
Serotonin 1e (5-HT1e) receptor | HTR1E | P28566 | CHEMBL2182 | Family A G protein-coupled receptor | 0.0 |
3 /
0   |
Histamine H4 receptor | HRH4 | Q9H3N8 | CHEMBL3759 | Family A G protein-coupled receptor | 0.0 |
0 /
3   |
Alpha-2a adrenergic receptor | ADRA2A | P08913 | CHEMBL1867 | Family A G protein-coupled receptor | 0.0 |
15 /
19   |
Vasopressin V1a receptor | AVPR1A | P37288 | CHEMBL1889 | Family A G protein-coupled receptor | 0.0 |
0 /
14   |
Epidermal growth factor receptor erbB1 | EGFR | P00533 | CHEMBL203 | Kinase | 0.0 |
2 /
3   |
Epoxide hydrolase 1 | EPHX1 | P07099 | CHEMBL1968 | Protease | 0.0 |
0 /
21   |
Glycine receptor subunit alpha-1 | GLRA1 | P23415 | CHEMBL5845 | Ligand-gated ion channel | 0.0 |
0 /
1   |
Steroid 5-alpha-reductase 1 | SRD5A1 | P18405 | CHEMBL1787 | Oxidoreductase | 0.0 |
0 /
28   |
C-C chemokine receptor type 1 | CCR1 | P32246 | CHEMBL2413 | Family A G protein-coupled receptor | 0.0 |
0 /
66   |
Dopamine D1 receptor | DRD1 | P21728 | CHEMBL2056 | Family A G protein-coupled receptor | 0.0 |
20 /
29   |
*Probability for the query molecule - assumed as bioactive - to have this protein as target.