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Swiss Institute of Bioinformatics
SwissTargetPrediction
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Query Molecule
Target Classes
Top 15
Top 25
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Export results:
Target | Common name | Uniprot ID | ChEMBL ID | Target Class | Probability* | Known actives (3D/2D) |
---|---|---|---|---|---|---|
Monoamine oxidase B | MAOB | P27338 | CHEMBL2039 | Oxidoreductase | 1.0 |
65 /
6   |
Indoleamine 2,3-dioxygenase | IDO1 | P14902 | CHEMBL4685 | Enzyme | 1.0 |
12 /
12   |
Dual specificity phosphatase Cdc25B | CDC25B | P30305 | CHEMBL4804 | Phosphatase | 1.0 |
11 /
11   |
Monoamine oxidase A | MAOA | P21397 | CHEMBL1951 | Oxidoreductase | 0.124537699969 |
24 /
2   |
Dual specificity mitogen-activated protein kinase kinase 1 | MAP2K1 | Q02750 | CHEMBL3587 | Kinase | 0.124537699969 |
3 /
1   |
Dual specificity protein phosphatase 1 (by homology) | DUSP1 | P28562 | CHEMBL6026 | Enzyme | 0.124537699969 |
2 /
2   |
Histone acetyltransferase p300 | EP300 | Q09472 | CHEMBL3784 | Writer | 0.080569968052 |
0 /
1   |
Serine/threonine-protein kinase PLK1 | PLK1 | P53350 | CHEMBL3024 | Kinase | 0.0717871625222 |
1 /
0   |
Monoglyceride lipase | MGLL | Q99685 | CHEMBL4191 | Enzyme | 0.0717871625222 |
20 /
0   |
Glycogen synthase kinase-3 beta | GSK3B | P49841 | CHEMBL262 | Kinase | 0.0717871625222 |
21 /
0   |
DNA-(apurinic or apyrimidinic site) lyase | APEX1 | P27695 | CHEMBL5619 | Enzyme | 0.0717871625222 |
0 /
11   |
Cytochrome P450 11B1 | CYP11B1 | P15538 | CHEMBL1908 | Cytochrome P450 | 0.0717871625222 |
6 /
0   |
Cytochrome P450 11B2 | CYP11B2 | P19099 | CHEMBL2722 | Cytochrome P450 | 0.0717871625222 |
5 /
0   |
Aryl hydrocarbon receptor | AHR | P35869 | CHEMBL3201 | Transcription factor | 0.0717871625222 |
23 /
0   |
Poly [ADP-ribose] polymerase-1 | PARP1 | P09874 | CHEMBL3105 | Enzyme | 0.0717871625222 |
39 /
0   |
Serine/threonine-protein kinase PIM1 | PIM1 | P11309 | CHEMBL2147 | Kinase | 0.0 |
0 /
3   |
Muscarinic acetylcholine receptor M4 | CHRM4 | P08173 | CHEMBL1821 | Family A G protein-coupled receptor | 0.0 |
5 /
0   |
Neuronal acetylcholine receptor; alpha4/beta2 | CHRNA4 CHRNB2 | P43681 P17787 | CHEMBL1907589 | Ligand-gated ion channel | 0.0 |
5 /
0   |
Muscarinic acetylcholine receptor M5 | CHRM5 | P08912 | CHEMBL2035 | Family A G protein-coupled receptor | 0.0 |
5 /
0   |
Muscarinic acetylcholine receptor M2 | CHRM2 | P08172 | CHEMBL211 | Family A G protein-coupled receptor | 0.0 |
11 /
0   |
Muscarinic acetylcholine receptor M1 | CHRM1 | P11229 | CHEMBL216 | Family A G protein-coupled receptor | 0.0 |
22 /
0   |
Muscarinic acetylcholine receptor M3 | CHRM3 | P20309 | CHEMBL245 | Family A G protein-coupled receptor | 0.0 |
5 /
0   |
Neuronal acetylcholine receptor protein alpha-7 subunit | CHRNA7 | P36544 | CHEMBL2492 | Ligand-gated ion channel | 0.0 |
1 /
0   |
Glutathione reductase | GSR | P00390 | CHEMBL2755 | Oxidoreductase | 0.0 |
2 /
4   |
Beta-secretase 1 | BACE1 | P56817 | CHEMBL4822 | Protease | 0.0 |
1 /
3   |
DNA (cytosine-5)-methyltransferase 1 | DNMT1 | P26358 | CHEMBL1993 | Writer | 0.0 |
1 /
1   |
DNMT3A2/3L complex | DNMT3L DNMT3A | Q9UJW3 Q9Y6K1 | CHEMBL3137291 | Reader | 0.0 |
1 /
1   |
Dopamine transporter | SLC6A3 | Q01959 | CHEMBL238 | Electrochemical transporter | 0.0 |
19 /
0   |
Cytochrome P450 2A6 | CYP2A6 | P11509 | CHEMBL5282 | Cytochrome P450 | 0.0 |
11 /
0   |
Hematopoietic prostaglandin D synthase | HPGDS | O60760 | CHEMBL5879 | Transferase | 0.0 |
1 /
0   |
Thyroid hormone receptor beta-1 | THRB | P10828 | CHEMBL1947 | Nuclear receptor | 0.0 |
0 /
2   |
G-protein coupled receptor 35 | GPR35 | Q9HC97 | CHEMBL1293267 | Family A G protein-coupled receptor | 0.0 |
0 /
1   |
Transient receptor potential cation channel subfamily A member 1 | TRPA1 | O75762 | CHEMBL6007 | Voltage-gated ion channel | 0.0 |
3 /
0   |
Acetylcholinesterase | ACHE | P22303 | CHEMBL220 | Hydrolase | 0.0 |
17 /
9   |
Nitric oxide synthase, inducible (by homology) | NOS2 | P35228 | CHEMBL4481 | Enzyme | 0.0 |
14 /
0   |
Histone deacetylase 8 | HDAC8 | Q9BY41 | CHEMBL3192 | Eraser | 0.0 |
1 /
0   |
Acyl coenzyme A:cholesterol acyltransferase 1 | SOAT1 | P35610 | CHEMBL2782 | Enzyme | 0.0 |
2 /
13   |
Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | MALT1 | Q9UDY8 | CHEMBL3632452 | Hydrolase | 0.0 |
6 /
0   |
Matrix metalloproteinase 2 | MMP2 | P08253 | CHEMBL333 | Protease | 0.0 |
1 /
0   |
Alcohol dehydrogenase alpha chain | ADH1A | P07327 | CHEMBL1970 | Oxidoreductase | 0.0 |
13 /
0   |
Poly [ADP-ribose] polymerase 3 | PARP3 | Q9Y6F1 | CHEMBL5083 | Enzyme | 0.0 |
1 /
0   |
Angiotensin-converting enzyme (by homology) | ACE | P12821 | CHEMBL1808 | Protease | 0.0 |
1 /
0   |
Lysine-specific demethylase 4D-like | KDM4E | B2RXH2 | CHEMBL1293226 | Eraser | 0.0 |
1 /
0   |
Tyrosyl-DNA phosphodiesterase 2 | TDP2 | O95551 | CHEMBL2169736 | Enzyme | 0.0 |
3 /
0   |
Mannose-6-phosphate isomerase | MPI | P34949 | CHEMBL2758 | Isomerase | 0.0 |
0 /
1   |
Signal transducer and activator of transcription 3 | STAT3 | P40763 | CHEMBL4026 | Transcription factor | 0.0 |
0 /
1   |
Norepinephrine transporter | SLC6A2 | P23975 | CHEMBL222 | Electrochemical transporter | 0.0 |
9 /
0   |
Serotonin transporter | SLC6A4 | P31645 | CHEMBL228 | Electrochemical transporter | 0.0 |
6 /
0   |
Cathepsin S | CTSS | P25774 | CHEMBL2954 | Protease | 0.0 |
4 /
0   |
Nitric-oxide synthase, brain | NOS1 | P29475 | CHEMBL3568 | Enzyme | 0.0 |
1 /
0   |
Cathepsin (B and K) | CTSB | P07858 | CHEMBL4072 | Protease | 0.0 |
5 /
0   |
11-beta-hydroxysteroid dehydrogenase 1 | HSD11B1 | P28845 | CHEMBL4235 | Enzyme | 0.0 |
18 /
0   |
Nitric-oxide synthase, endothelial | NOS3 | P29474 | CHEMBL4803 | Enzyme | 0.0 |
1 /
0   |
Telomerase reverse transcriptase | TERT | O14746 | CHEMBL2916 | Enzyme | 0.0 |
4 /
0   |
Histone acetyltransferase PCAF | KAT2B | Q92831 | CHEMBL5500 | Writer | 0.0 |
6 /
0   |
Caspase-3 | CASP3 | P42574 | CHEMBL2334 | Protease | 0.0 |
3 /
0   |
Sigma opioid receptor | SIGMAR1 | Q99720 | CHEMBL287 | Membrane receptor | 0.0 |
2 /
0   |
Lysine-specific demethylase 4C | KDM4C | Q9H3R0 | CHEMBL6175 | Eraser | 0.0 |
6 /
0   |
Phosphodiesterase 7A | PDE7A | Q13946 | CHEMBL3012 | Phosphodiesterase | 0.0 |
7 /
0   |
Alcohol dehydrogenase beta chain | ADH1B | P00325 | CHEMBL3284 | Oxidoreductase | 0.0 |
7 /
0   |
Alcohol dehydrogenase gamma chain | ADH1C | P00326 | CHEMBL3285 | Oxidoreductase | 0.0 |
4 /
0   |
Carbonic anhydrase VII | CA7 | P43166 | CHEMBL2326 | Lyase | 0.0 |
6 /
0   |
Carbonic anhydrase XIV | CA14 | Q9ULX7 | CHEMBL3510 | Lyase | 0.0 |
8 /
0   |
Inosine-5'-monophosphate dehydrogenase 2 | IMPDH2 | P12268 | CHEMBL2002 | Oxidoreductase | 0.0 |
1 /
0   |
GABA-A receptor; alpha-5/beta-3/gamma-2 | GABRB3 GABRG2 GABRA5 | P28472 P18507 P31644 | CHEMBL2094122 | Ligand-gated ion channel | 0.0 |
7 /
0   |
c-Jun N-terminal kinase 1 | MAPK8 | P45983 | CHEMBL2276 | Kinase | 0.0 |
12 /
0   |
Regulator of G-protein signaling 4 | RGS4 | P49798 | CHEMBL1795091 | Unclassified protein | 0.0 |
1 /
0   |
Thrombin | F2 | P00734 | CHEMBL204 | Protease | 0.0 |
4 /
0   |
Adenosine A1 receptor | ADORA1 | P30542 | CHEMBL226 | Family A G protein-coupled receptor | 0.0 |
3 /
0   |
Chymotrypsin C | CTRC | Q99895 | CHEMBL2386 | Protease | 0.0 |
1 /
0   |
Leukocyte elastase | ELANE | P08246 | CHEMBL248 | Protease | 0.0 |
4 /
0   |
Adenosine A2a receptor | ADORA2A | P29274 | CHEMBL251 | Family A G protein-coupled receptor | 0.0 |
4 /
0   |
Cathepsin G | CTSG | P08311 | CHEMBL4071 | Protease | 0.0 |
1 /
0   |
Phosphodiesterase 4B | PDE4B | Q07343 | CHEMBL275 | Phosphodiesterase | 0.0 |
1 /
0   |
Phosphodiesterase 4D | PDE4D | Q08499 | CHEMBL288 | Phosphodiesterase | 0.0 |
1 /
0   |
Alpha-2a adrenergic receptor | ADRA2A | P08913 | CHEMBL1867 | Family A G protein-coupled receptor | 0.0 |
1 /
0   |
Adrenergic receptor alpha-2 | ADRA2C | P18825 | CHEMBL1916 | Family A G protein-coupled receptor | 0.0 |
1 /
0   |
Alpha-2b adrenergic receptor | ADRA2B | P18089 | CHEMBL1942 | Family A G protein-coupled receptor | 0.0 |
1 /
0   |
Alpha-1d adrenergic receptor | ADRA1D | P25100 | CHEMBL223 | Family A G protein-coupled receptor | 0.0 |
1 /
0   |
Alpha-1a adrenergic receptor | ADRA1A | P35348 | CHEMBL229 | Family A G protein-coupled receptor | 0.0 |
1 /
0   |
Alpha-1b adrenergic receptor | ADRA1B | P35368 | CHEMBL232 | Family A G protein-coupled receptor | 0.0 |
1 /
0   |
Thymidine phosphorylase | TYMP | P19971 | CHEMBL3106 | Enzyme | 0.0 |
6 /
0   |
MAP kinase ERK2 | MAPK1 | P28482 | CHEMBL4040 | Kinase | 0.0 |
1 /
0   |
N-acylsphingosine-amidohydrolase (by homology) | NAAA | Q02083 | CHEMBL4349 | Enzyme | 0.0 |
9 /
0   |
Thyroid peroxidase | TPO | P07202 | CHEMBL1839 | Oxidoreductase | 0.0 |
1 /
0   |
Dipeptidyl peptidase I | CTSC | P53634 | CHEMBL2252 | Protease | 0.0 |
2 /
0   |
Myeloperoxidase | MPO | P05164 | CHEMBL2439 | Enzyme | 0.0 |
3 /
0   |
Carbonic anhydrase VB | CA5B | Q9Y2D0 | CHEMBL3969 | Lyase | 0.0 |
3 /
0   |
Carbonic anhydrase XIII (by homology) | CA13 | Q8N1Q1 | CHEMBL3912 | Lyase | 0.0 |
4 /
0   |
Tyrosine-protein kinase SYK | SYK | P43405 | CHEMBL2599 | Kinase | 0.0 |
2 /
0   |
Hormone sensitive lipase | LIPE | Q05469 | CHEMBL3590 | Enzyme | 0.0 |
1 /
0   |
Cathepsin L | CTSL | P07711 | CHEMBL3837 | Protease | 0.0 |
5 /
0   |
Adenosine A3 receptor | ADORA3 | P0DMS8 | CHEMBL256 | Family A G protein-coupled receptor | 0.0 |
3 /
0   |
Protein-glutamine gamma-glutamyltransferase | TGM2 | P21980 | CHEMBL2730 | Enzyme | 0.0 |
7 /
0   |
Metabotropic glutamate receptor 5 (by homology) | GRM5 | P41594 | CHEMBL3227 | Family C G protein-coupled receptor | 0.0 |
12 /
0   |
Neuronal acetylcholine receptor; alpha3/beta4 | CHRNA3 CHRNB4 | P32297 P30926 | CHEMBL1907594 | Ligand-gated ion channel | 0.0 |
1 /
0   |
Macrophage migration inhibitory factor | MIF | P14174 | CHEMBL2085 | Enzyme | 0.0 |
2 /
0   |
Trypsin I | PRSS1 | P07477 | CHEMBL209 | Protease | 0.0 |
2 /
0   |
Heme oxygenase 1 (by homology) | HMOX1 | P09601 | CHEMBL2823 | Enzyme | 0.0 |
6 /
0   |
Serotonin 7 (5-HT7) receptor | HTR7 | P34969 | CHEMBL3155 | Family A G protein-coupled receptor | 0.0 |
1 /
0   |
*Probability for the query molecule - assumed as bioactive - to have this protein as target.