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Swiss Institute of Bioinformatics
SwissTargetPrediction
Query Molecule






Target Classes
Top 15
Top 25
Top 50
All
Export results:
Target | Common name | Uniprot ID | ChEMBL ID | Target Class | Probability* | Known actives (3D/2D) |
---|---|---|---|---|---|---|
Dopamine transporter | SLC6A3 | Q01959 | CHEMBL238 | Electrochemical transporter | 0.102879010863 |
1152 /
148   |
Serotonin transporter | SLC6A4 | P31645 | CHEMBL228 | Electrochemical transporter | 0.0721804396226 |
1407 /
114   |
Norepinephrine transporter | SLC6A2 | P23975 | CHEMBL222 | Electrochemical transporter | 0.0619149311119 |
880 /
99   |
Neuronal acetylcholine receptor; alpha4/beta2 | CHRNA4 CHRNB2 | P43681 P17787 | CHEMBL1907589 | Ligand-gated ion channel | 0.0414702990123 |
261 /
6   |
Neuronal acetylcholine receptor; alpha3/beta4 | CHRNA3 CHRNB4 | P32297 P30926 | CHEMBL1907594 | Ligand-gated ion channel | 0.0312265582077 |
139 /
4   |
Dopamine D2 receptor (by homology) | DRD2 | P14416 | CHEMBL217 | Family A G protein-coupled receptor | 0.0312265582077 |
1095 /
74   |
Dopamine D3 receptor | DRD3 | P35462 | CHEMBL234 | Family A G protein-coupled receptor | 0.0312265582077 |
389 /
50   |
Metastin receptor | KISS1R | Q969F8 | CHEMBL5413 | Family A G protein-coupled receptor | 0.0312265582077 |
5 /
0   |
Serotonin 3a (5-HT3a) receptor | HTR3A | P46098 | CHEMBL1899 | Ligand-gated ion channel | 0.0312265582077 |
67 /
0   |
Protein arginine N-methyltransferase 6 | PRMT6 | Q96LA8 | CHEMBL1275221 | Writer | 0.0312265582077 |
6 /
0   |
Histone-arginine methyltransferase CARM1 | CARM1 | Q86X55 | CHEMBL5406 | Writer | 0.0312265582077 |
2 /
0   |
Neuronal acetylcholine receptor protein alpha-4 subunit | CHRNA4 | P43681 | CHEMBL1882 | Ligand-gated ion channel | 0.0312265582077 |
74 /
0   |
Sodium channel protein type V alpha subunit | SCN5A | Q14524 | CHEMBL1980 | Voltage-gated ion channel | 0.0312265582077 |
1 /
0   |
Poly [ADP-ribose] polymerase-1 | PARP1 | P09874 | CHEMBL3105 | Enzyme | 0.0312265582077 |
203 /
0   |
Histamine H4 receptor | HRH4 | Q9H3N8 | CHEMBL3759 | Family A G protein-coupled receptor | 0.0312265582077 |
143 /
0   |
Sodium channel protein type II alpha subunit | SCN2A | Q99250 | CHEMBL4187 | Voltage-gated ion channel | 0.0312265582077 |
1 /
0   |
Dipeptidyl peptidase IX | DPP9 | Q86TI2 | CHEMBL4793 | Protease | 0.0312265582077 |
91 /
0   |
Dihydropteridine reductase | QDPR | P09417 | CHEMBL3730 | Enzyme | 0.0312265582077 |
6 /
0   |
Acetylcholine receptor; alpha1/beta1/delta/gamma | CHRNB1 CHRNA1 CHRNG CHRND | P11230 P02708 P07510 Q07001 | CHEMBL1907588 | Ligand-gated ion channel | 0.0312265582077 |
14 /
2   |
Dopamine D5 receptor | DRD5 | P21918 | CHEMBL1850 | Family A G protein-coupled receptor | 0.0312265582077 |
77 /
0   |
Anti-estrogen binding site (AEBS) | EBP | Q15125 | CHEMBL4931 | Enzyme | 0.0312265582077 |
3 /
0   |
Indoleamine 2,3-dioxygenase | IDO1 | P14902 | CHEMBL4685 | Enzyme | 0.0312265582077 |
2 /
0   |
Serotonin 1f (5-HT1f) receptor | HTR1F | P30939 | CHEMBL1805 | Family A G protein-coupled receptor | 0.0312265582077 |
41 /
0   |
Bromodomain-containing protein 4 | BRD4 | O60885 | CHEMBL1163125 | Reader | 0.0312265582077 |
7 /
0   |
Neuronal acetylcholine receptor protein alpha-7 subunit | CHRNA7 | P36544 | CHEMBL2492 | Ligand-gated ion channel | 0.0312265582077 |
174 /
1   |
Ribosomal protein S6 kinase 1 | RPS6KB1 | P23443 | CHEMBL4501 | Kinase | 0.0312265582077 |
5 /
0   |
Serine/threonine-protein kinase Aurora-A | AURKA | O14965 | CHEMBL4722 | Kinase | 0.0312265582077 |
11 /
0   |
Serotonin 1e (5-HT1e) receptor | HTR1E | P28566 | CHEMBL2182 | Family A G protein-coupled receptor | 0.0312265582077 |
6 /
0   |
Phospholipase D1 | PLD1 | Q13393 | CHEMBL2536 | Hydrolase | 0.0312265582077 |
15 /
0   |
Rho-associated protein kinase 1 | ROCK1 | Q13464 | CHEMBL3231 | Kinase | 0.0312265582077 |
59 /
0   |
Neuronal acetylcholine receptor subunit alpha-3 | CHRNA3 | P32297 | CHEMBL3068 | Ligand-gated ion channel | 0.0312265582077 |
12 /
0   |
Hormone sensitive lipase | LIPE | Q05469 | CHEMBL3590 | Enzyme | 0.0312265582077 |
1 /
0   |
Calcium sensing receptor | CASR | P41180 | CHEMBL1878 | Family C G protein-coupled receptor | 0.0312265582077 |
11 /
0   |
Tyrosine-protein kinase JAK3 | JAK3 | P52333 | CHEMBL2148 | Kinase | 0.0312265582077 |
24 /
0   |
Acyl coenzyme A:cholesterol acyltransferase | CES1 | P23141 | CHEMBL2265 | Enzyme | 0.0312265582077 |
0 /
24   |
Tyrosine-protein kinase JAK1 | JAK1 | P23458 | CHEMBL2835 | Kinase | 0.0312265582077 |
64 /
0   |
Tyrosine-protein kinase JAK2 | JAK2 | O60674 | CHEMBL2971 | Kinase | 0.0312265582077 |
48 /
0   |
Carboxylesterase 2 | CES2 | O00748 | CHEMBL3180 | Enzyme | 0.0312265582077 |
0 /
29   |
Tyrosine-protein kinase TYK2 | TYK2 | P29597 | CHEMBL3553 | Kinase | 0.0312265582077 |
14 /
0   |
Sodium channel protein type IV alpha subunit | SCN4A | P35499 | CHEMBL2072 | Voltage-gated ion channel | 0.0 |
13 /
0   |
PDZ-binding kinase | PBK | Q96KB5 | CHEMBL4896 | Kinase | 0.0 |
14 /
0   |
Rho-associated protein kinase | ROCK2 ROCK1 | O75116 Q13464 | CHEMBL2111459 | Kinase | 0.0 |
39 /
0   |
Poly [ADP-ribose] polymerase 2 | PARP2 | Q9UGN5 | CHEMBL5366 | Enzyme | 0.0 |
14 /
0   |
Phosphodiesterase 7A | PDE7A | Q13946 | CHEMBL3012 | Phosphodiesterase | 0.0 |
5 /
0   |
Serine/threonine-protein kinase haspin | HASPIN | Q8TF76 | CHEMBL1075163 | Kinase | 0.0 |
15 /
0   |
Nischarin | NISCH | Q9Y2I1 | CHEMBL3923 | Other cytosolic protein | 0.0 |
1 /
0   |
Serine/threonine-protein kinase Chk1 | CHEK1 | O14757 | CHEMBL4630 | Kinase | 0.0 |
58 /
0   |
Protein arginine N-methyltransferase 3 | PRMT3 | O60678 | CHEMBL5891 | Writer | 0.0 |
4 /
0   |
Bromodomain adjacent to zinc finger domain protein 2A | BAZ2A | Q9UIF9 | CHEMBL3108642 | Reader | 0.0 |
1 /
0   |
Nociceptin receptor | OPRL1 | P41146 | CHEMBL2014 | Family A G protein-coupled receptor | 0.0 |
94 /
0   |
Nitric-oxide synthase, brain | NOS1 | P29475 | CHEMBL3568 | Enzyme | 0.0 |
102 /
0   |
Serotonin 4 (5-HT4) receptor | HTR4 | Q13639 | CHEMBL1875 | Family A G protein-coupled receptor | 0.0 |
19 /
0   |
Melatonin receptor 1A | MTNR1A | P48039 | CHEMBL1945 | Family A G protein-coupled receptor | 0.0 |
2 /
19   |
Glutamate NMDA receptor; GRIN1/GRIN2B | GRIN1 GRIN2B | Q05586 Q13224 | CHEMBL1907603 | Ligand-gated ion channel | 0.0 |
2 /
0   |
Glutamate NMDA receptor; GRIN1/GRIN2A | GRIN2A GRIN1 | Q12879 Q05586 | CHEMBL1907604 | Ligand-gated ion channel | 0.0 |
3 /
0   |
Serine/threonine-protein kinase PIM1 | PIM1 | P11309 | CHEMBL2147 | Kinase | 0.0 |
60 /
0   |
Protein arginine N-methyltransferase 8 | PRMT8 | Q9NR22 | CHEMBL3108648 | Writer | 0.0 |
5 /
0   |
Serine/threonine-protein kinase PIM2 | PIM2 | Q9P1W9 | CHEMBL4523 | Kinase | 0.0 |
40 /
0   |
Serine/threonine-protein kinase PIM3 | PIM3 | Q86V86 | CHEMBL5407 | Kinase | 0.0 |
15 /
0   |
Serotonin 2a (5-HT2a) receptor | HTR2A | P28223 | CHEMBL224 | Family A G protein-coupled receptor | 0.0 |
626 /
26   |
Rho-associated protein kinase 2 | ROCK2 | O75116 | CHEMBL2973 | Kinase | 0.0 |
129 /
0   |
Nuclear receptor subfamily 4 group A member 1 | NR4A1 | P22736 | CHEMBL1293229 | Nuclear receptor | 0.0 |
1 /
0   |
Cyclin-dependent kinase 9 | CDK9 | P50750 | CHEMBL3116 | Kinase | 0.0 |
41 /
0   |
Nitric oxide synthase, inducible | NOS2 | P35228 | CHEMBL4481 | Enzyme | 0.0 |
57 /
0   |
Dual-specificity tyrosine-phosphorylation regulated kinase 2 | DYRK2 | Q92630 | CHEMBL4376 | Kinase | 0.0 |
5 /
0   |
Phosphodiesterase 10A | PDE10A | Q9Y233 | CHEMBL4409 | Phosphodiesterase | 0.0 |
1 /
0   |
Somatostatin receptor 3 | SSTR3 | P32745 | CHEMBL2028 | Family A G protein-coupled receptor | 0.0 |
21 /
0   |
Solute carrier family 22 member 2 | SLC22A2 | O15244 | CHEMBL1743122 | Electrochemical transporter | 0.0 |
1 /
0   |
Multidrug and toxin extrusion protein 1 | SLC47A1 | Q96FL8 | CHEMBL1743126 | Electrochemical transporter | 0.0 |
1 /
0   |
Serotonin 3 (5-HT3) receptor | HTR3B HTR3A | O95264 P46098 | CHEMBL2111332 | Ligand-gated ion channel | 0.0 |
2 /
0   |
Neuropeptide Y receptor type 5 | NPY5R | Q15761 | CHEMBL4561 | Family A G protein-coupled receptor | 0.0 |
2 /
0   |
Adenylate cyclase type V | ADCY5 | O95622 | CHEMBL3189 | Enzyme | 0.0 |
2 /
0   |
Lethal(3)malignant brain tumor-like protein 3 | L3MBTL3 | Q96JM7 | CHEMBL1287623 | Reader | 0.0 |
11 /
0   |
Cytochrome P450 1A2 | CYP1A2 | P05177 | CHEMBL3356 | Cytochrome P450 | 0.0 |
2 /
0   |
Quinone reductase 2 | NQO2 | P16083 | CHEMBL3959 | Enzyme | 0.0 |
7 /
0   |
Tankyrase-2 | TNKS2 | Q9H2K2 | CHEMBL6154 | Enzyme | 0.0 |
1 /
0   |
Inhibitor of nuclear factor kappa B kinase beta subunit | IKBKB | O14920 | CHEMBL1991 | Kinase | 0.0 |
27 /
0   |
Tyrosine- and threonine-specific cdc2-inhibitory kinase | PKMYT1 | Q99640 | CHEMBL3984 | Kinase | 0.0 |
1 /
0   |
Gamma-amino-N-butyrate transaminase (by homology) | ABAT | P80404 | CHEMBL2044 | Transferase | 0.0 |
9 /
0   |
C-C motif chemokine 2 | CCL2 | P13500 | CHEMBL1649052 | Family A G protein-coupled receptor | 0.0 |
3 /
0   |
Myosin light chain kinase, smooth muscle | MYLK | Q15746 | CHEMBL2428 | Kinase | 0.0 |
2 /
0   |
Protein kinase C delta | PRKCD | Q05655 | CHEMBL2996 | Kinase | 0.0 |
35 /
0   |
Protein kinase N2 | PKN2 | Q16513 | CHEMBL3032 | Kinase | 0.0 |
13 /
0   |
Protein kinase N1 | PKN1 | Q16512 | CHEMBL3384 | Kinase | 0.0 |
5 /
0   |
Protein kinase C epsilon | PRKCE | Q02156 | CHEMBL3582 | Kinase | 0.0 |
21 /
0   |
Protein kinase C mu | PRKD1 | Q15139 | CHEMBL3863 | Kinase | 0.0 |
5 /
0   |
Ribosomal protein S6 kinase alpha 5 | RPS6KA5 | O75582 | CHEMBL4237 | Kinase | 0.0 |
4 /
0   |
Histone acetyltransferase PCAF | KAT2B | Q92831 | CHEMBL5500 | Writer | 0.0 |
6 /
0   |
Toll-like receptor (TLR7/TLR9) | TLR9 | Q9NR96 | CHEMBL5804 | Toll-like and Il-1 receptors | 0.0 |
1 /
0   |
Serine/threonine-protein kinase PRKX | PRKX | P51817 | CHEMBL5818 | Kinase | 0.0 |
2 /
0   |
Dipeptidyl peptidase IV | DPP4 | P27487 | CHEMBL284 | Protease | 0.0 |
806 /
12   |
Nitric-oxide synthase, endothelial | NOS3 | P29474 | CHEMBL4803 | Enzyme | 0.0 |
29 /
0   |
Purine nucleoside phosphorylase | PNP | P00491 | CHEMBL4338 | Enzyme | 0.0 |
1 /
0   |
Tyrosine-protein kinase SYK | SYK | P43405 | CHEMBL2599 | Kinase | 0.0 |
26 /
0   |
Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | MALT1 | Q9UDY8 | CHEMBL3632452 | Hydrolase | 0.0 |
3 /
0   |
Neuronal acetylcholine receptor; alpha3/alpha6/beta2/beta3 | CHRNB3 CHRNA6 CHRNB2 CHRNA3 | Q05901 Q15825 P17787 P32297 | CHEMBL2109233 | Ligand-gated ion channel | 0.0 |
8 /
0   |
Glycogen synthase kinase-3 beta | GSK3B | P49841 | CHEMBL262 | Kinase | 0.0 |
4 /
0   |
Rho GDP-dissociation inhibitor 1 | ARHGDIA | P52565 | CHEMBL3638327 | Unclassified protein | 0.0 |
2 /
0   |
Sigma opioid receptor | SIGMAR1 | Q99720 | CHEMBL287 | Membrane receptor | 0.0 |
549 /
58   |
Histone deacetylase 2 | HDAC2 | Q92769 | CHEMBL1937 | Eraser | 0.0 |
1 /
0   |
*Probability for the query molecule - assumed as bioactive - to have this protein as target.