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Query Molecule
Target Classes
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Export results:
Target Common name Uniprot ID ChEMBL ID Target Class Probability* Known actives (3D/2D)
Serotonin transporter SLC6A4 P31645 CHEMBL228 Electrochemical transporter 1.0
1486 / 862     
Sigma opioid receptor SIGMAR1 Q99720 CHEMBL287 Membrane receptor 1.0
627 / 717     
Dopamine D2 receptor (by homology) DRD2 P14416 CHEMBL217 Family A G protein-coupled receptor 0.673980204067
1102 / 1097     
Neuronal acetylcholine receptor; alpha4/beta2 CHRNA4 CHRNB2 P43681 P17787 CHEMBL1907589 Ligand-gated ion channel 0.428280861155
178 / 38     
Neuronal acetylcholine receptor; alpha3/beta4 CHRNA3 CHRNB4 P32297 P30926 CHEMBL1907594 Ligand-gated ion channel 0.428280861155
96 / 19     
Neuronal acetylcholine receptor protein alpha-7 subunit CHRNA7 P36544 CHEMBL2492 Ligand-gated ion channel 0.428280861155
131 / 8     
Mu opioid receptor OPRM1 P35372 CHEMBL233 Family A G protein-coupled receptor 0.362674718576
672 / 1730     
Dopamine D4 receptor DRD4 P21917 CHEMBL219 Family A G protein-coupled receptor 0.329868485421
224 / 127     
Dopamine D3 receptor DRD3 P35462 CHEMBL234 Family A G protein-coupled receptor 0.329868485421
410 / 543     
Serotonin 1a (5-HT1a) receptor HTR1A P08908 CHEMBL214 Family A G protein-coupled receptor 0.321690506669
445 / 249     
Kappa Opioid receptor OPRK1 P41145 CHEMBL237 Family A G protein-coupled receptor 0.313572766871
483 / 1035     
Delta opioid receptor OPRD1 P41143 CHEMBL236 Family A G protein-coupled receptor 0.288928252457
481 / 1407     
Glutamate NMDA receptor; GRIN1/GRIN2A GRIN2A GRIN1 Q12879 Q05586 CHEMBL1907604 Ligand-gated ion channel 0.280808559877
5 / 10     
Norepinephrine transporter SLC6A2 P23975 CHEMBL222 Electrochemical transporter 0.239574695827
932 / 423     
Dopamine transporter SLC6A3 Q01959 CHEMBL238 Electrochemical transporter 0.239574695827
1299 / 774     
Dopamine D1 receptor DRD1 P21728 CHEMBL2056 Family A G protein-coupled receptor 0.215238178243
175 / 184     
Alpha-1d adrenergic receptor ADRA1D P25100 CHEMBL223 Family A G protein-coupled receptor 0.157929217109
13 / 35     
Alpha-1a adrenergic receptor ADRA1A P35348 CHEMBL229 Family A G protein-coupled receptor 0.157929217109
22 / 82     
Alpha-1b adrenergic receptor ADRA1B P35368 CHEMBL232 Family A G protein-coupled receptor 0.141522086267
15 / 55     
Serotonin 5a (5-HT5a) receptor HTR5A P47898 CHEMBL3426 Family A G protein-coupled receptor 0.133337961498
33 / 23     
Dopamine D5 receptor DRD5 P21918 CHEMBL1850 Family A G protein-coupled receptor 0.133337961498
75 / 67     
Muscarinic acetylcholine receptor M2 CHRM2 P08172 CHEMBL211 Family A G protein-coupled receptor 0.133337961498
153 / 57     
11-beta-hydroxysteroid dehydrogenase 1 HSD11B1 P28845 CHEMBL4235 Enzyme 0.125142648574
26 / 286     
Anti-estrogen binding site (AEBS) EBP Q15125 CHEMBL4931 Enzyme 0.125142648574
3 / 13     
Muscarinic acetylcholine receptor M1 CHRM1 P11229 CHEMBL216 Family A G protein-coupled receptor 0.116965063224
257 / 47     
Synaptic vesicular amine transporter (by homology) SLC18A2 Q05940 CHEMBL1893 Electrochemical transporter 0.116965063224
17 / 162     
Serotonin 1b (5-HT1b) receptor (by homology) HTR1B P28222 CHEMBL1898 Family A G protein-coupled receptor 0.108770969359
169 / 52     
Steroid 5-alpha-reductase 1 SRD5A1 P18405 CHEMBL1787 Oxidoreductase 0.108770969359
0 / 33     
Glutamate [NMDA] receptor subunit epsilon 2 GRIN2B Q13224 CHEMBL1904 Ligand-gated ion channel 0.108770969359
8 / 18     
Serotonin 2c (5-HT2c) receptor HTR2C P28335 CHEMBL225 Family A G protein-coupled receptor 0.108770969359
242 / 133     
Serotonin 2a (5-HT2a) receptor HTR2A P28223 CHEMBL224 Family A G protein-coupled receptor 0.100578902067
490 / 387     
Alpha-2a adrenergic receptor ADRA2A P08913 CHEMBL1867 Family A G protein-coupled receptor 0.100578902067
16 / 18     
Adrenergic receptor alpha-2 ADRA2C P18825 CHEMBL1916 Family A G protein-coupled receptor 0.100578902067
30 / 23     
Serotonin 2b (5-HT2b) receptor HTR2B P41595 CHEMBL1833 Family A G protein-coupled receptor 0.100578902067
128 / 86     
Histamine H2 receptor HRH2 P25021 CHEMBL1941 Family A G protein-coupled receptor 0.100578902067
17 / 21     
Serotonin 7 (5-HT7) receptor HTR7 P34969 CHEMBL3155 Family A G protein-coupled receptor 0.100578902067
170 / 35     
Dipeptidyl peptidase IV DPP4 P27487 CHEMBL284 Protease 0.100578902067
461 / 103     
DNA polymerase alpha subunit POLA1 P09884 CHEMBL1828 Transferase 0.100578902067
1 / 13     
Alpha-2b adrenergic receptor ADRA2B P18089 CHEMBL1942 Family A G protein-coupled receptor 0.100578902067
16 / 15     
Histamine H3 receptor HRH3 Q9Y5N1 CHEMBL264 Family A G protein-coupled receptor 0.100578902067
248 / 296     
Serotonin 1d (5-HT1d) receptor HTR1D P28221 CHEMBL1983 Family A G protein-coupled receptor 0.100578902067
127 / 48     
Lysine-specific histone demethylase 1 KDM1A O60341 CHEMBL6136 Eraser 0.100578902067
73 / 55     
Adenosine A3 receptor ADORA3 P0DMS8 CHEMBL256 Family A G protein-coupled receptor 0.100578902067
3 / 5     
Neuropeptide Y receptor type 5 NPY5R Q15761 CHEMBL4561 Family A G protein-coupled receptor 0.100578902067
2 / 40     
Voltage-gated L-type calcium channel alpha-1C subunit CACNA1C Q13936 CHEMBL1940 Voltage-gated ion channel 0.100578902067
0 / 3     
P-glycoprotein 1 ABCB1 P08183 CHEMBL4302 Primary active transporter 0.100578902067
5 / 52     
HERG KCNH2 Q12809 CHEMBL240 Voltage-gated ion channel 0.100578902067
239 / 118     
Acetylcholinesterase ACHE P22303 CHEMBL220 Hydrolase 0.100578902067
75 / 210     
Melatonin receptor 1A MTNR1A P48039 CHEMBL1945 Family A G protein-coupled receptor 0.100578902067
2 / 167     
Melatonin receptor 1B MTNR1B P49286 CHEMBL1946 Family A G protein-coupled receptor 0.100578902067
4 / 155     
Putative hydrolase RBBP9 RBBP9 O75884 CHEMBL1075121 Enzyme 0.100578902067
0 / 1     
Small conductance calcium-activated potassium channel protein 1 KCNN1 Q92952 CHEMBL2369 Voltage-gated ion channel 0.100578902067
0 / 1     
Small conductance calcium-activated potassium channel protein 3 KCNN3 Q9UGI6 CHEMBL3381 Voltage-gated ion channel 0.100578902067
0 / 1     
Small conductance calcium-activated potassium channel protein 2 KCNN2 Q9H2S1 CHEMBL4469 Voltage-gated ion channel 0.100578902067
0 / 1     
Toll-like receptor 4 (by homology) TLR4 O00206 CHEMBL5255 Toll-like and Il-1 receptors 0.100578902067
0 / 11     
Histamine H1 receptor HRH1 P35367 CHEMBL231 Family A G protein-coupled receptor 0.100578902067
130 / 45     
Solute carrier family 22 member 1 SLC22A1 O15245 CHEMBL5685 Electrochemical transporter 0.100578902067
0 / 1     
Nociceptin receptor OPRL1 P41146 CHEMBL2014 Family A G protein-coupled receptor 0.100578902067
181 / 93     
PH domain leucine-rich repeat-containing protein phosphatase 2 PHLPP2 Q6ZVD8 CHEMBL1275209 Enzyme 0.100578902067
1 / 0     
LXR-alpha NR1H3 Q13133 CHEMBL2808 Nuclear receptor 0.100578902067
0 / 25     
LXR-beta NR1H2 P55055 CHEMBL4093 Nuclear receptor 0.100578902067
0 / 24     
Sodium channel protein type IV alpha subunit SCN4A P35499 CHEMBL2072 Voltage-gated ion channel 0.100578902067
13 / 0     
Rho-associated protein kinase 1 ROCK1 Q13464 CHEMBL3231 Kinase 0.100578902067
27 / 0     
Rho-associated protein kinase 2 ROCK2 O75116 CHEMBL2973 Kinase 0.100578902067
93 / 0     
Neuronal acetylcholine receptor; alpha3/alpha6/beta2/beta3 CHRNB3 CHRNA6 CHRNB2 CHRNA3 Q05901 Q15825 P17787 P32297 CHEMBL2109233 Ligand-gated ion channel 0.100578902067
7 / 0     
Serotonin 1e (5-HT1e) receptor HTR1E P28566 CHEMBL2182 Family A G protein-coupled receptor 0.100578902067
9 / 0     
Rho-associated protein kinase ROCK2 ROCK1 O75116 Q13464 CHEMBL2111459 Kinase 0.100578902067
50 / 0     
Muscarinic acetylcholine receptor M5 CHRM5 P08912 CHEMBL2035 Family A G protein-coupled receptor 0.100578902067
64 / 28     
Muscarinic acetylcholine receptor M3 CHRM3 P20309 CHEMBL245 Family A G protein-coupled receptor 0.100578902067
104 / 50     
Tyrosine-protein kinase JAK3 JAK3 P52333 CHEMBL2148 Kinase 0.100578902067
14 / 0     
Tyrosine-protein kinase JAK1 JAK1 P23458 CHEMBL2835 Kinase 0.100578902067
43 / 0     
Tyrosine-protein kinase JAK2 JAK2 O60674 CHEMBL2971 Kinase 0.100578902067
33 / 0     
Tyrosine-protein kinase TYK2 TYK2 P29597 CHEMBL3553 Kinase 0.100578902067
11 / 0     
Tyrosine-protein kinase LCK LCK P06239 CHEMBL258 Kinase 0.100578902067
1 / 1     
Carbonic anhydrase II CA2 P00918 CHEMBL205 Lyase 0.100578902067
21 / 24     
Carbonic anhydrase I CA1 P00915 CHEMBL261 Lyase 0.100578902067
12 / 17     
Quinone reductase 2 NQO2 P16083 CHEMBL3959 Enzyme 0.100578902067
5 / 31     
Glutamate NMDA receptor; GRIN1/GRIN2B GRIN1 GRIN2B Q05586 Q13224 CHEMBL1907603 Ligand-gated ion channel 0.100578902067
3 / 22     
Arachidonate 5-lipoxygenase ALOX5 P09917 CHEMBL215 Oxidoreductase 0.100578902067
0 / 16     
Butyrylcholinesterase BCHE P06276 CHEMBL1914 Hydrolase 0.100578902067
24 / 34     
Rho GDP-dissociation inhibitor 1 ARHGDIA P52565 CHEMBL3638327 Unclassified protein 0.100578902067
3 / 0     
Histamine H4 receptor HRH4 Q9H3N8 CHEMBL3759 Family A G protein-coupled receptor 0.100578902067
86 / 0     
Tyrosine-protein kinase FYN FYN P06241 CHEMBL1841 Kinase 0.100578902067
0 / 2     
Carbonic anhydrase VII CA7 P43166 CHEMBL2326 Lyase 0.100578902067
0 / 1     
Carbonic anhydrase III CA3 P07451 CHEMBL2885 Lyase 0.100578902067
0 / 1     
Carbonic anhydrase VI CA6 P23280 CHEMBL3025 Lyase 0.100578902067
0 / 8     
Carbonic anhydrase IV CA4 P22748 CHEMBL3729 Lyase 0.100578902067
0 / 8     
Carbonic anhydrase XIII CA13 Q8N1Q1 CHEMBL3912 Lyase 0.100578902067
0 / 1     
Carbonic anhydrase VB CA5B Q9Y2D0 CHEMBL3969 Lyase 0.100578902067
0 / 1     
Carbonic anhydrase VA CA5A P35218 CHEMBL4789 Lyase 0.100578902067
0 / 1     
Serotonin 3a (5-HT3a) receptor HTR3A P46098 CHEMBL1899 Ligand-gated ion channel 0.100578902067
73 / 0     
Calcium-activated potassium channel subunit alpha-1 KCNMA1 Q12791 CHEMBL4304 Voltage-gated ion channel 0.100578902067
1 / 0     
Nitric-oxide synthase, brain NOS1 P29475 CHEMBL3568 Enzyme 0.100578902067
74 / 0     
Cytochrome P450 24A1 (by homology) CYP24A1 Q07973 CHEMBL4521 Enzyme 0.100578902067
0 / 7     
Indoleamine 2,3-dioxygenase IDO1 P14902 CHEMBL4685 Enzyme 0.0
1 / 0     
Serotonin 6 (5-HT6) receptor HTR6 P50406 CHEMBL3371 Family A G protein-coupled receptor 0.0
214 / 27     
Neuronal acetylcholine receptor protein alpha-4 subunit CHRNA4 P43681 CHEMBL1882 Ligand-gated ion channel 0.0
28 / 0     
Protein tyrosine phosphatase receptor type C-associated protein PTPRCAP Q14761 CHEMBL4806 Enzyme 0.0
1 / 0     
Epoxide hydratase EPHX2 P34913 CHEMBL2409 Protease 0.0
6 / 33     
Neurokinin 1 receptor TACR1 P25103 CHEMBL249 Family A G protein-coupled receptor 0.0
62 / 146     

*Probability for the query molecule - assumed as bioactive - to have this protein as target.