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Query Molecule
Target Classes
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Export results:
Target Common name Uniprot ID ChEMBL ID Target Class Probability* Known actives (3D/2D)
Serotonin transporter SLC6A4 P31645 CHEMBL228 Electrochemical transporter 0.361585490895
635 / 675     
Dopamine transporter SLC6A3 Q01959 CHEMBL238 Electrochemical transporter 0.361585490895
527 / 701     
Norepinephrine transporter SLC6A2 P23975 CHEMBL222 Electrochemical transporter 0.221211439369
359 / 381     
Sigma opioid receptor SIGMAR1 Q99720 CHEMBL287 Membrane receptor 0.221211439369
238 / 531     
Serotonin 2a (5-HT2a) receptor HTR2A P28223 CHEMBL224 Family A G protein-coupled receptor 0.212408695957
252 / 122     
Serotonin 2c (5-HT2c) receptor HTR2C P28335 CHEMBL225 Family A G protein-coupled receptor 0.194838675314
204 / 73     
Dopamine D2 receptor (by homology) DRD2 P14416 CHEMBL217 Family A G protein-coupled receptor 0.185778875656
205 / 357     
Synaptic vesicular amine transporter (by homology) SLC18A2 Q05940 CHEMBL1893 Electrochemical transporter 0.177302605236
18 / 127     
Histamine H1 receptor HRH1 P35367 CHEMBL231 Family A G protein-coupled receptor 0.15964807511
40 / 35     
Monoamine oxidase B MAOB P27338 CHEMBL2039 Oxidoreductase 0.150923844771
43 / 51     
HERG KCNH2 Q12809 CHEMBL240 Voltage-gated ion channel 0.133316407552
56 / 62     
Monoamine oxidase A MAOA P21397 CHEMBL1951 Oxidoreductase 0.133316407552
49 / 45     
Lysine-specific histone demethylase 1 KDM1A O60341 CHEMBL6136 Eraser 0.133316407552
33 / 63     
Dopamine D3 receptor (by homology) DRD3 P35462 CHEMBL234 Family A G protein-coupled receptor 0.106926671721
103 / 145     
Amine oxidase, copper containing AOC3 Q16853 CHEMBL3437 Enzyme 0.0893704742941
0 / 13     
Neuronal acetylcholine receptor; alpha3/beta4 CHRNA3 CHRNB4 P32297 P30926 CHEMBL1907594 Ligand-gated ion channel 0.0893704742941
11 / 11     
Serotonin 2b (5-HT2b) receptor HTR2B P41595 CHEMBL1833 Family A G protein-coupled receptor 0.0893704742941
86 / 44     
Trace amine-associated receptor 1 (by homology) TAAR1 Q96RJ0 CHEMBL5857 Family A G protein-coupled receptor 0.080569968052
5 / 8     
3-phosphoinositide dependent protein kinase-1 PDPK1 O15530 CHEMBL2534 Kinase 0.080569968052
1 / 1     
Serotonin 5a (5-HT5a) receptor (by homology) HTR5A P47898 CHEMBL3426 Family A G protein-coupled receptor 0.080569968052
12 / 16     
Leukotriene A4 hydrolase LTA4H P09960 CHEMBL4618 Protease 0.080569968052
0 / 5     
Glutamate [NMDA] receptor subunit epsilon 2 GRIN2B Q13224 CHEMBL1904 Ligand-gated ion channel 0.080569968052
2 / 17     
Serotonin 1a (5-HT1a) receptor HTR1A P08908 CHEMBL214 Family A G protein-coupled receptor 0.080569968052
58 / 50     
C-C chemokine receptor type 3 CCR3 P51677 CHEMBL3473 Family A G protein-coupled receptor 0.080569968052
1 / 7     
Kinesin-1 heavy chain/ Tyrosine-protein kinase receptor RET RET P07949 CHEMBL2041 Kinase 0.080569968052
4 / 0     
Mu opioid receptor OPRM1 P35372 CHEMBL233 Family A G protein-coupled receptor 0.080569968052
30 / 484     
Vesicular acetylcholine transporter SLC18A3 Q16572 CHEMBL4767 Electrochemical transporter 0.080569968052
1 / 59     
LSD1/CoREST complex RCOR1 KDM1A Q9UKL0 O60341 CHEMBL3137262 Eraser 0.0717871625222
23 / 29     
Melanocortin receptor 4 MC4R P32245 CHEMBL259 Family A G protein-coupled receptor 0.0717871625222
0 / 13     
Sphingosine kinase 2 (by homology) SPHK2 Q9NRA0 CHEMBL3023 Enzyme 0.0717871625222
0 / 6     
Alpha-2b adrenergic receptor ADRA2B P18089 CHEMBL1942 Family A G protein-coupled receptor 0.0717871625222
25 / 11     
Histamine H3 receptor HRH3 Q9Y5N1 CHEMBL264 Family A G protein-coupled receptor 0.0717871625222
52 / 96     
Solute carrier family 22 member 2 SLC22A2 O15244 CHEMBL1743122 Electrochemical transporter 0.0717871625222
1 / 0     
Multidrug and toxin extrusion protein 1 SLC47A1 Q96FL8 CHEMBL1743126 Electrochemical transporter 0.0717871625222
1 / 0     
Kappa Opioid receptor OPRK1 P41145 CHEMBL237 Family A G protein-coupled receptor 0.0717871625222
21 / 257     
Thyroid hormone receptor alpha THRA P10827 CHEMBL1860 Nuclear receptor 0.0717871625222
0 / 9     
Thyroid hormone receptor beta-1 THRB P10828 CHEMBL1947 Nuclear receptor 0.0717871625222
0 / 10     
Protein arginine N-methyltransferase 6 PRMT6 Q96LA8 CHEMBL1275221 Writer 0.0717871625222
0 / 1     
Protein arginine N-methyltransferase 8 PRMT8 Q9NR22 CHEMBL3108648 Writer 0.0717871625222
0 / 1     
Histone-arginine methyltransferase CARM1 CARM1 Q86X55 CHEMBL5406 Writer 0.0717871625222
0 / 1     
Lysosomal Pro-X carboxypeptidase PRCP P42785 CHEMBL2335 Protease 0.0717871625222
15 / 3     
Neuronal acetylcholine receptor; alpha2/beta4 CHRNB4 CHRNA2 P30926 Q15822 CHEMBL2109230 Ligand-gated ion channel 0.0717871625222
1 / 0     
Neuronal acetylcholine receptor; alpha3/beta2 CHRNA3 CHRNB2 P32297 P17787 CHEMBL2109234 Ligand-gated ion channel 0.0717871625222
1 / 0     
Neuronal acetylcholine receptor; alpha4/beta2 CHRNA4 CHRNB2 P43681 P17787 CHEMBL1907589 Ligand-gated ion channel 0.0717871625222
26 / 21     
Glutamate [NMDA] receptor PROTEIN GRIN1 Q05586 CHEMBL2015 Ligand-gated ion channel 0.0717871625222
1 / 0     
Melanocortin receptor 5 MC5R P33032 CHEMBL4608 Family A G protein-coupled receptor 0.0717871625222
2 / 0     
Kinesin-like protein 1 KIF11 P52732 CHEMBL4581 Other cytosolic protein 0.0717871625222
8 / 24     
Alpha-1a adrenergic receptor (by homology) ADRA1A P35348 CHEMBL229 Family A G protein-coupled receptor 0.0717871625222
28 / 38     
Serotonin 3a (5-HT3a) receptor HTR3A P46098 CHEMBL1899 Ligand-gated ion channel 0.0717871625222
13 / 2     
Protein tyrosine kinase 2 beta PTK2B Q14289 CHEMBL5469 Kinase 0.0717871625222
1 / 0     
Muscarinic acetylcholine receptor M5 CHRM5 P08912 CHEMBL2035 Family A G protein-coupled receptor 0.0717871625222
23 / 20     
Delta opioid receptor OPRD1 P41143 CHEMBL236 Family A G protein-coupled receptor 0.0717871625222
13 / 255     
Melatonin receptor 1A MTNR1A P48039 CHEMBL1945 Family A G protein-coupled receptor 0.0717871625222
0 / 40     
Melatonin receptor 1B MTNR1B P49286 CHEMBL1946 Family A G protein-coupled receptor 0.0717871625222
0 / 33     
Epoxide hydratase EPHX2 P34913 CHEMBL2409 Protease 0.0717871625222
0 / 27     
Acetylcholinesterase ACHE P22303 CHEMBL220 Hydrolase 0.0717871625222
9 / 23     
Adrenergic receptor alpha-2 ADRA2C P18825 CHEMBL1916 Family A G protein-coupled receptor 0.0717871625222
26 / 6     
Beta-1 adrenergic receptor ADRB1 P08588 CHEMBL213 Family A G protein-coupled receptor 0.0
9 / 3     
Adenosine A3 receptor ADORA3 P0DMS8 CHEMBL256 Family A G protein-coupled receptor 0.0
3 / 6     
Alpha-2a adrenergic receptor ADRA2A P08913 CHEMBL1867 Family A G protein-coupled receptor 0.0
26 / 11     
Serotonin 6 (5-HT6) receptor HTR6 P50406 CHEMBL3371 Family A G protein-coupled receptor 0.0
77 / 8     
Anti-estrogen binding site (AEBS) EBP Q15125 CHEMBL4931 Enzyme 0.0
1 / 10     
Alpha-1d adrenergic receptor ADRA1D P25100 CHEMBL223 Family A G protein-coupled receptor 0.0
14 / 11     
Serotonin 1e (5-HT1e) receptor HTR1E P28566 CHEMBL2182 Family A G protein-coupled receptor 0.0
7 / 0     
Sphingosine 1-phosphate receptor Edg-8 S1PR5 Q9H228 CHEMBL2274 Family A G protein-coupled receptor 0.0
0 / 2     
Sphingosine 1-phosphate receptor Edg-6 S1PR4 O95977 CHEMBL3230 Family A G protein-coupled receptor 0.0
0 / 9     
Sphingosine 1-phosphate receptor Edg-3 S1PR3 Q99500 CHEMBL3892 Family A G protein-coupled receptor 0.0
0 / 13     
Sphingosine 1-phosphate receptor Edg-1 S1PR1 P21453 CHEMBL4333 Family A G protein-coupled receptor 0.0
0 / 14     
Carbonic anhydrase II CA2 P00918 CHEMBL205 Lyase 0.0
0 / 5     
Adrenergic receptor beta ADRB2 P07550 CHEMBL210 Family A G protein-coupled receptor 0.0
0 / 7     
Tyrosine-protein kinase LCK LCK P06239 CHEMBL258 Kinase 0.0
0 / 1     
Carbonic anhydrase I CA1 P00915 CHEMBL261 Lyase 0.0
0 / 5     
Prion protein PRNP P04156 CHEMBL4869 Surface antigen 0.0
3 / 0     
Interferon-alpha/beta receptor alpha chain IFNAR1 P17181 CHEMBL1887 Membrane receptor 0.0
1 / 0     
Muscarinic acetylcholine receptor M2 CHRM2 P08172 CHEMBL211 Family A G protein-coupled receptor 0.0
31 / 28     
Dipeptidyl peptidase I CTSC P53634 CHEMBL2252 Protease 0.0
0 / 3     
Cathepsin K CTSK P43235 CHEMBL268 Protease 0.0
0 / 3     
Cathepsin S CTSS P25774 CHEMBL2954 Protease 0.0
0 / 2     
Cathepsin L CTSL P07711 CHEMBL3837 Protease 0.0
0 / 1     
Cathepsin (B and K) CTSB P07858 CHEMBL4072 Protease 0.0
0 / 2     
Voltage-gated potassium channel subunit Kv1.3 KCNA3 P22001 CHEMBL4633 Voltage-gated ion channel 0.0
0 / 7     
Glutamate NMDA receptor; GRIN1/GRIN2B GRIN1 GRIN2B Q05586 Q13224 CHEMBL1907603 Ligand-gated ion channel 0.0
2 / 6     
Histone-lysine N-methyltransferase SETD7 SETD7 Q8WTS6 CHEMBL5523 Writer 0.0
3 / 0     
Cytochrome P450 2A6 CYP2A6 P11509 CHEMBL5282 Cytochrome P450 0.0
1 / 1     
Muscarinic acetylcholine receptor M4 CHRM4 P08173 CHEMBL1821 Family A G protein-coupled receptor 0.0
20 / 22     
Muscarinic acetylcholine receptor M1 CHRM1 P11229 CHEMBL216 Family A G protein-coupled receptor 0.0
32 / 21     
Voltage-gated calcium channel alpha2/delta subunit 1 (by homology) CACNA2D1 P54289 CHEMBL1919 Calcium channel auxiliary subunit alpha2delta family 0.0
0 / 2     
Histamine H2 receptor HRH2 P25021 CHEMBL1941 Family A G protein-coupled receptor 0.0
17 / 5     
Epoxide hydrolase 1 EPHX1 P07099 CHEMBL1968 Protease 0.0
0 / 6     
Sodium channel protein type IV alpha subunit SCN4A P35499 CHEMBL2072 Voltage-gated ion channel 0.0
4 / 0     
C-X-C chemokine receptor type 3 CXCR3 P49682 CHEMBL4441 Family A G protein-coupled receptor 0.0
15 / 0     
Serine/threonine-protein kinase PIM1 PIM1 P11309 CHEMBL2147 Kinase 0.0
2 / 0     
Cytochrome P450 2D6 CYP2D6 P10635 CHEMBL289 Cytochrome P450 0.0
5 / 4     
Myeloperoxidase MPO P05164 CHEMBL2439 Enzyme 0.0
19 / 0     
Glutamate NMDA receptor; GRIN1/GRIN2A GRIN2A GRIN1 Q12879 Q05586 CHEMBL1907604 Ligand-gated ion channel 0.0
2 / 5     
Potassium channel subfamily K member 2 KCNK2 O95069 CHEMBL2321615 Voltage-gated ion channel 0.0
1 / 0     
P-glycoprotein 1 ABCB1 P08183 CHEMBL4302 Primary active transporter 0.0
1 / 0     
Calmodulin CALM1 P62158 CHEMBL6093 Unclassified protein 0.0
1 / 0     
Sodium channel protein type IX alpha subunit SCN9A Q15858 CHEMBL4296 Voltage-gated ion channel 0.0
1 / 0     
11-beta-hydroxysteroid dehydrogenase 1 HSD11B1 P28845 CHEMBL4235 Enzyme 0.0
0 / 24     

*Probability for the query molecule - assumed as bioactive - to have this protein as target.