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Swiss Institute of Bioinformatics
SwissTargetPrediction
Query Molecule





Target Classes
Top 15
Top 25
Top 50
All
Export results:
Target | Common name | Uniprot ID | ChEMBL ID | Target Class | Probability* | Known actives (3D/2D) |
---|---|---|---|---|---|---|
Serotonin transporter | SLC6A4 | P31645 | CHEMBL228 | Electrochemical transporter | 0.361585490895 |
635 /
675   |
Dopamine transporter | SLC6A3 | Q01959 | CHEMBL238 | Electrochemical transporter | 0.361585490895 |
527 /
701   |
Norepinephrine transporter | SLC6A2 | P23975 | CHEMBL222 | Electrochemical transporter | 0.221211439369 |
359 /
381   |
Sigma opioid receptor | SIGMAR1 | Q99720 | CHEMBL287 | Membrane receptor | 0.221211439369 |
238 /
531   |
Serotonin 2a (5-HT2a) receptor | HTR2A | P28223 | CHEMBL224 | Family A G protein-coupled receptor | 0.212408695957 |
252 /
122   |
Serotonin 2c (5-HT2c) receptor | HTR2C | P28335 | CHEMBL225 | Family A G protein-coupled receptor | 0.194838675314 |
204 /
73   |
Dopamine D2 receptor (by homology) | DRD2 | P14416 | CHEMBL217 | Family A G protein-coupled receptor | 0.185778875656 |
205 /
357   |
Synaptic vesicular amine transporter (by homology) | SLC18A2 | Q05940 | CHEMBL1893 | Electrochemical transporter | 0.177302605236 |
18 /
127   |
Histamine H1 receptor | HRH1 | P35367 | CHEMBL231 | Family A G protein-coupled receptor | 0.15964807511 |
40 /
35   |
Monoamine oxidase B | MAOB | P27338 | CHEMBL2039 | Oxidoreductase | 0.150923844771 |
43 /
51   |
HERG | KCNH2 | Q12809 | CHEMBL240 | Voltage-gated ion channel | 0.133316407552 |
56 /
62   |
Monoamine oxidase A | MAOA | P21397 | CHEMBL1951 | Oxidoreductase | 0.133316407552 |
49 /
45   |
Lysine-specific histone demethylase 1 | KDM1A | O60341 | CHEMBL6136 | Eraser | 0.133316407552 |
33 /
63   |
Dopamine D3 receptor (by homology) | DRD3 | P35462 | CHEMBL234 | Family A G protein-coupled receptor | 0.106926671721 |
103 /
145   |
Amine oxidase, copper containing | AOC3 | Q16853 | CHEMBL3437 | Enzyme | 0.0893704742941 |
0 /
13   |
Neuronal acetylcholine receptor; alpha3/beta4 | CHRNA3 CHRNB4 | P32297 P30926 | CHEMBL1907594 | Ligand-gated ion channel | 0.0893704742941 |
11 /
11   |
Serotonin 2b (5-HT2b) receptor | HTR2B | P41595 | CHEMBL1833 | Family A G protein-coupled receptor | 0.0893704742941 |
86 /
44   |
Trace amine-associated receptor 1 (by homology) | TAAR1 | Q96RJ0 | CHEMBL5857 | Family A G protein-coupled receptor | 0.080569968052 |
5 /
8   |
3-phosphoinositide dependent protein kinase-1 | PDPK1 | O15530 | CHEMBL2534 | Kinase | 0.080569968052 |
1 /
1   |
Serotonin 5a (5-HT5a) receptor (by homology) | HTR5A | P47898 | CHEMBL3426 | Family A G protein-coupled receptor | 0.080569968052 |
12 /
16   |
Leukotriene A4 hydrolase | LTA4H | P09960 | CHEMBL4618 | Protease | 0.080569968052 |
0 /
5   |
Glutamate [NMDA] receptor subunit epsilon 2 | GRIN2B | Q13224 | CHEMBL1904 | Ligand-gated ion channel | 0.080569968052 |
2 /
17   |
Serotonin 1a (5-HT1a) receptor | HTR1A | P08908 | CHEMBL214 | Family A G protein-coupled receptor | 0.080569968052 |
58 /
50   |
C-C chemokine receptor type 3 | CCR3 | P51677 | CHEMBL3473 | Family A G protein-coupled receptor | 0.080569968052 |
1 /
7   |
Kinesin-1 heavy chain/ Tyrosine-protein kinase receptor RET | RET | P07949 | CHEMBL2041 | Kinase | 0.080569968052 |
4 /
0   |
Mu opioid receptor | OPRM1 | P35372 | CHEMBL233 | Family A G protein-coupled receptor | 0.080569968052 |
30 /
484   |
Vesicular acetylcholine transporter | SLC18A3 | Q16572 | CHEMBL4767 | Electrochemical transporter | 0.080569968052 |
1 /
59   |
LSD1/CoREST complex | RCOR1 KDM1A | Q9UKL0 O60341 | CHEMBL3137262 | Eraser | 0.0717871625222 |
23 /
29   |
Melanocortin receptor 4 | MC4R | P32245 | CHEMBL259 | Family A G protein-coupled receptor | 0.0717871625222 |
0 /
13   |
Sphingosine kinase 2 (by homology) | SPHK2 | Q9NRA0 | CHEMBL3023 | Enzyme | 0.0717871625222 |
0 /
6   |
Alpha-2b adrenergic receptor | ADRA2B | P18089 | CHEMBL1942 | Family A G protein-coupled receptor | 0.0717871625222 |
25 /
11   |
Histamine H3 receptor | HRH3 | Q9Y5N1 | CHEMBL264 | Family A G protein-coupled receptor | 0.0717871625222 |
52 /
96   |
Solute carrier family 22 member 2 | SLC22A2 | O15244 | CHEMBL1743122 | Electrochemical transporter | 0.0717871625222 |
1 /
0   |
Multidrug and toxin extrusion protein 1 | SLC47A1 | Q96FL8 | CHEMBL1743126 | Electrochemical transporter | 0.0717871625222 |
1 /
0   |
Kappa Opioid receptor | OPRK1 | P41145 | CHEMBL237 | Family A G protein-coupled receptor | 0.0717871625222 |
21 /
257   |
Thyroid hormone receptor alpha | THRA | P10827 | CHEMBL1860 | Nuclear receptor | 0.0717871625222 |
0 /
9   |
Thyroid hormone receptor beta-1 | THRB | P10828 | CHEMBL1947 | Nuclear receptor | 0.0717871625222 |
0 /
10   |
Protein arginine N-methyltransferase 6 | PRMT6 | Q96LA8 | CHEMBL1275221 | Writer | 0.0717871625222 |
0 /
1   |
Protein arginine N-methyltransferase 8 | PRMT8 | Q9NR22 | CHEMBL3108648 | Writer | 0.0717871625222 |
0 /
1   |
Histone-arginine methyltransferase CARM1 | CARM1 | Q86X55 | CHEMBL5406 | Writer | 0.0717871625222 |
0 /
1   |
Lysosomal Pro-X carboxypeptidase | PRCP | P42785 | CHEMBL2335 | Protease | 0.0717871625222 |
15 /
3   |
Neuronal acetylcholine receptor; alpha2/beta4 | CHRNB4 CHRNA2 | P30926 Q15822 | CHEMBL2109230 | Ligand-gated ion channel | 0.0717871625222 |
1 /
0   |
Neuronal acetylcholine receptor; alpha3/beta2 | CHRNA3 CHRNB2 | P32297 P17787 | CHEMBL2109234 | Ligand-gated ion channel | 0.0717871625222 |
1 /
0   |
Neuronal acetylcholine receptor; alpha4/beta2 | CHRNA4 CHRNB2 | P43681 P17787 | CHEMBL1907589 | Ligand-gated ion channel | 0.0717871625222 |
26 /
21   |
Glutamate [NMDA] receptor PROTEIN | GRIN1 | Q05586 | CHEMBL2015 | Ligand-gated ion channel | 0.0717871625222 |
1 /
0   |
Melanocortin receptor 5 | MC5R | P33032 | CHEMBL4608 | Family A G protein-coupled receptor | 0.0717871625222 |
2 /
0   |
Kinesin-like protein 1 | KIF11 | P52732 | CHEMBL4581 | Other cytosolic protein | 0.0717871625222 |
8 /
24   |
Alpha-1a adrenergic receptor (by homology) | ADRA1A | P35348 | CHEMBL229 | Family A G protein-coupled receptor | 0.0717871625222 |
28 /
38   |
Serotonin 3a (5-HT3a) receptor | HTR3A | P46098 | CHEMBL1899 | Ligand-gated ion channel | 0.0717871625222 |
13 /
2   |
Protein tyrosine kinase 2 beta | PTK2B | Q14289 | CHEMBL5469 | Kinase | 0.0717871625222 |
1 /
0   |
Muscarinic acetylcholine receptor M5 | CHRM5 | P08912 | CHEMBL2035 | Family A G protein-coupled receptor | 0.0717871625222 |
23 /
20   |
Delta opioid receptor | OPRD1 | P41143 | CHEMBL236 | Family A G protein-coupled receptor | 0.0717871625222 |
13 /
255   |
Melatonin receptor 1A | MTNR1A | P48039 | CHEMBL1945 | Family A G protein-coupled receptor | 0.0717871625222 |
0 /
40   |
Melatonin receptor 1B | MTNR1B | P49286 | CHEMBL1946 | Family A G protein-coupled receptor | 0.0717871625222 |
0 /
33   |
Epoxide hydratase | EPHX2 | P34913 | CHEMBL2409 | Protease | 0.0717871625222 |
0 /
27   |
Acetylcholinesterase | ACHE | P22303 | CHEMBL220 | Hydrolase | 0.0717871625222 |
9 /
23   |
Adrenergic receptor alpha-2 | ADRA2C | P18825 | CHEMBL1916 | Family A G protein-coupled receptor | 0.0717871625222 |
26 /
6   |
Beta-1 adrenergic receptor | ADRB1 | P08588 | CHEMBL213 | Family A G protein-coupled receptor | 0.0 |
9 /
3   |
Adenosine A3 receptor | ADORA3 | P0DMS8 | CHEMBL256 | Family A G protein-coupled receptor | 0.0 |
3 /
6   |
Alpha-2a adrenergic receptor | ADRA2A | P08913 | CHEMBL1867 | Family A G protein-coupled receptor | 0.0 |
26 /
11   |
Serotonin 6 (5-HT6) receptor | HTR6 | P50406 | CHEMBL3371 | Family A G protein-coupled receptor | 0.0 |
77 /
8   |
Anti-estrogen binding site (AEBS) | EBP | Q15125 | CHEMBL4931 | Enzyme | 0.0 |
1 /
10   |
Alpha-1d adrenergic receptor | ADRA1D | P25100 | CHEMBL223 | Family A G protein-coupled receptor | 0.0 |
14 /
11   |
Serotonin 1e (5-HT1e) receptor | HTR1E | P28566 | CHEMBL2182 | Family A G protein-coupled receptor | 0.0 |
7 /
0   |
Sphingosine 1-phosphate receptor Edg-8 | S1PR5 | Q9H228 | CHEMBL2274 | Family A G protein-coupled receptor | 0.0 |
0 /
2   |
Sphingosine 1-phosphate receptor Edg-6 | S1PR4 | O95977 | CHEMBL3230 | Family A G protein-coupled receptor | 0.0 |
0 /
9   |
Sphingosine 1-phosphate receptor Edg-3 | S1PR3 | Q99500 | CHEMBL3892 | Family A G protein-coupled receptor | 0.0 |
0 /
13   |
Sphingosine 1-phosphate receptor Edg-1 | S1PR1 | P21453 | CHEMBL4333 | Family A G protein-coupled receptor | 0.0 |
0 /
14   |
Carbonic anhydrase II | CA2 | P00918 | CHEMBL205 | Lyase | 0.0 |
0 /
5   |
Adrenergic receptor beta | ADRB2 | P07550 | CHEMBL210 | Family A G protein-coupled receptor | 0.0 |
0 /
7   |
Tyrosine-protein kinase LCK | LCK | P06239 | CHEMBL258 | Kinase | 0.0 |
0 /
1   |
Carbonic anhydrase I | CA1 | P00915 | CHEMBL261 | Lyase | 0.0 |
0 /
5   |
Prion protein | PRNP | P04156 | CHEMBL4869 | Surface antigen | 0.0 |
3 /
0   |
Interferon-alpha/beta receptor alpha chain | IFNAR1 | P17181 | CHEMBL1887 | Membrane receptor | 0.0 |
1 /
0   |
Muscarinic acetylcholine receptor M2 | CHRM2 | P08172 | CHEMBL211 | Family A G protein-coupled receptor | 0.0 |
31 /
28   |
Dipeptidyl peptidase I | CTSC | P53634 | CHEMBL2252 | Protease | 0.0 |
0 /
3   |
Cathepsin K | CTSK | P43235 | CHEMBL268 | Protease | 0.0 |
0 /
3   |
Cathepsin S | CTSS | P25774 | CHEMBL2954 | Protease | 0.0 |
0 /
2   |
Cathepsin L | CTSL | P07711 | CHEMBL3837 | Protease | 0.0 |
0 /
1   |
Cathepsin (B and K) | CTSB | P07858 | CHEMBL4072 | Protease | 0.0 |
0 /
2   |
Voltage-gated potassium channel subunit Kv1.3 | KCNA3 | P22001 | CHEMBL4633 | Voltage-gated ion channel | 0.0 |
0 /
7   |
Glutamate NMDA receptor; GRIN1/GRIN2B | GRIN1 GRIN2B | Q05586 Q13224 | CHEMBL1907603 | Ligand-gated ion channel | 0.0 |
2 /
6   |
Histone-lysine N-methyltransferase SETD7 | SETD7 | Q8WTS6 | CHEMBL5523 | Writer | 0.0 |
3 /
0   |
Cytochrome P450 2A6 | CYP2A6 | P11509 | CHEMBL5282 | Cytochrome P450 | 0.0 |
1 /
1   |
Muscarinic acetylcholine receptor M4 | CHRM4 | P08173 | CHEMBL1821 | Family A G protein-coupled receptor | 0.0 |
20 /
22   |
Muscarinic acetylcholine receptor M1 | CHRM1 | P11229 | CHEMBL216 | Family A G protein-coupled receptor | 0.0 |
32 /
21   |
Voltage-gated calcium channel alpha2/delta subunit 1 (by homology) | CACNA2D1 | P54289 | CHEMBL1919 | Calcium channel auxiliary subunit alpha2delta family | 0.0 |
0 /
2   |
Histamine H2 receptor | HRH2 | P25021 | CHEMBL1941 | Family A G protein-coupled receptor | 0.0 |
17 /
5   |
Epoxide hydrolase 1 | EPHX1 | P07099 | CHEMBL1968 | Protease | 0.0 |
0 /
6   |
Sodium channel protein type IV alpha subunit | SCN4A | P35499 | CHEMBL2072 | Voltage-gated ion channel | 0.0 |
4 /
0   |
C-X-C chemokine receptor type 3 | CXCR3 | P49682 | CHEMBL4441 | Family A G protein-coupled receptor | 0.0 |
15 /
0   |
Serine/threonine-protein kinase PIM1 | PIM1 | P11309 | CHEMBL2147 | Kinase | 0.0 |
2 /
0   |
Cytochrome P450 2D6 | CYP2D6 | P10635 | CHEMBL289 | Cytochrome P450 | 0.0 |
5 /
4   |
Myeloperoxidase | MPO | P05164 | CHEMBL2439 | Enzyme | 0.0 |
19 /
0   |
Glutamate NMDA receptor; GRIN1/GRIN2A | GRIN2A GRIN1 | Q12879 Q05586 | CHEMBL1907604 | Ligand-gated ion channel | 0.0 |
2 /
5   |
Potassium channel subfamily K member 2 | KCNK2 | O95069 | CHEMBL2321615 | Voltage-gated ion channel | 0.0 |
1 /
0   |
P-glycoprotein 1 | ABCB1 | P08183 | CHEMBL4302 | Primary active transporter | 0.0 |
1 /
0   |
Calmodulin | CALM1 | P62158 | CHEMBL6093 | Unclassified protein | 0.0 |
1 /
0   |
Sodium channel protein type IX alpha subunit | SCN9A | Q15858 | CHEMBL4296 | Voltage-gated ion channel | 0.0 |
1 /
0   |
11-beta-hydroxysteroid dehydrogenase 1 | HSD11B1 | P28845 | CHEMBL4235 | Enzyme | 0.0 |
0 /
24   |
*Probability for the query molecule - assumed as bioactive - to have this protein as target.