In order to avoid security-related warning messages when switching to secured connection, you may want either to:
- confirm the exception on the next page, or
- import our CA key in your web browser
Click here to proceed.
Swiss Institute of Bioinformatics
SwissTargetPrediction
Query Molecule






Target Classes
Top 15
Top 25
Top 50
All
Export results:
Target | Common name | Uniprot ID | ChEMBL ID | Target Class | Probability* | Known actives (3D/2D) |
---|---|---|---|---|---|---|
Serotonin transporter | SLC6A4 | P31645 | CHEMBL228 | Electrochemical transporter | 0.0721804396226 |
1064 /
113   |
Dopamine transporter | SLC6A3 | Q01959 | CHEMBL238 | Electrochemical transporter | 0.0721804396226 |
850 /
131   |
Norepinephrine transporter | SLC6A2 | P23975 | CHEMBL222 | Electrochemical transporter | 0.0619149311119 |
602 /
68   |
Neuronal acetylcholine receptor; alpha4/beta2 | CHRNA4 CHRNB2 | P43681 P17787 | CHEMBL1907589 | Ligand-gated ion channel | 0.0312265582077 |
138 /
0   |
Neuronal acetylcholine receptor protein alpha-7 subunit | CHRNA7 | P36544 | CHEMBL2492 | Ligand-gated ion channel | 0.0312265582077 |
105 /
0   |
Neuronal acetylcholine receptor; alpha3/beta2 | CHRNA3 CHRNB2 | P32297 P17787 | CHEMBL2109234 | Ligand-gated ion channel | 0.0312265582077 |
7 /
0   |
Adrenergic receptor alpha-2 | ADRA2C | P18825 | CHEMBL1916 | Family A G protein-coupled receptor | 0.0312265582077 |
15 /
0   |
Cytochrome P450 2D6 | CYP2D6 | P10635 | CHEMBL289 | Cytochrome P450 | 0.0312265582077 |
4 /
0   |
Cytochrome P450 2C19 | CYP2C19 | P33261 | CHEMBL3622 | Cytochrome P450 | 0.0312265582077 |
2 /
0   |
Neuronal acetylcholine receptor protein alpha-4 subunit | CHRNA4 | P43681 | CHEMBL1882 | Ligand-gated ion channel | 0.0312265582077 |
36 /
0   |
Alpha-1d adrenergic receptor | ADRA1D | P25100 | CHEMBL223 | Family A G protein-coupled receptor | 0.0312265582077 |
4 /
0   |
Alpha-1b adrenergic receptor | ADRA1B | P35368 | CHEMBL232 | Family A G protein-coupled receptor | 0.0312265582077 |
5 /
0   |
Tyrosine- and threonine-specific cdc2-inhibitory kinase | PKMYT1 | Q99640 | CHEMBL3984 | Kinase | 0.0312265582077 |
1 /
0   |
Serine/threonine-protein kinase Chk1 | CHEK1 | O14757 | CHEMBL4630 | Kinase | 0.0312265582077 |
9 /
0   |
Sigma opioid receptor | SIGMAR1 | Q99720 | CHEMBL287 | Membrane receptor | 0.0312265582077 |
155 /
83   |
Serotonin 1b (5-HT1b) receptor | HTR1B | P28222 | CHEMBL1898 | Family A G protein-coupled receptor | 0.0312265582077 |
55 /
0   |
Serotonin 1d (5-HT1d) receptor | HTR1D | P28221 | CHEMBL1983 | Family A G protein-coupled receptor | 0.0312265582077 |
40 /
0   |
Nitric-oxide synthase, brain | NOS1 | P29475 | CHEMBL3568 | Enzyme | 0.0312265582077 |
32 /
0   |
Nitric oxide synthase, inducible | NOS2 | P35228 | CHEMBL4481 | Enzyme | 0.0312265582077 |
29 /
0   |
Dipeptidyl peptidase IV | DPP4 | P27487 | CHEMBL284 | Protease | 0.0312265582077 |
305 /
0   |
Cytochrome P450 11B2 | CYP11B2 | P19099 | CHEMBL2722 | Cytochrome P450 | 0.0312265582077 |
1 /
0   |
Serotonin 1a (5-HT1a) receptor | HTR1A | P08908 | CHEMBL214 | Family A G protein-coupled receptor | 0.0312265582077 |
109 /
0   |
Dopamine D2 receptor | DRD2 | P14416 | CHEMBL217 | Family A G protein-coupled receptor | 0.0312265582077 |
343 /
34   |
Phenylethanolamine N-methyltransferase | PNMT | P11086 | CHEMBL4617 | Enzyme | 0.0312265582077 |
25 /
0   |
Neuronal acetylcholine receptor; alpha4/beta4 | CHRNB4 CHRNA4 | P30926 P43681 | CHEMBL1907591 | Ligand-gated ion channel | 0.0312265582077 |
3 /
0   |
Neuronal acetylcholine receptor; alpha2/beta4 | CHRNB4 CHRNA2 | P30926 Q15822 | CHEMBL2109230 | Ligand-gated ion channel | 0.0312265582077 |
2 /
0   |
Epoxide hydratase | EPHX2 | P34913 | CHEMBL2409 | Protease | 0.0312265582077 |
2 /
0   |
Acetylcholine receptor protein alpha chain | CHRNA1 | P02708 | CHEMBL4808 | Ligand-gated ion channel | 0.0312265582077 |
2 /
0   |
Serotonin 6 (5-HT6) receptor | HTR6 | P50406 | CHEMBL3371 | Family A G protein-coupled receptor | 0.0312265582077 |
186 /
0   |
Acetylcholine receptor; alpha1/beta1/delta/gamma | CHRNB1 CHRNA1 CHRNG CHRND | P11230 P02708 P07510 Q07001 | CHEMBL1907588 | Ligand-gated ion channel | 0.0 |
8 /
0   |
Lysosomal Pro-X carboxypeptidase | PRCP | P42785 | CHEMBL2335 | Protease | 0.0 |
3 /
0   |
Serotonin 7 (5-HT7) receptor | HTR7 | P34969 | CHEMBL3155 | Family A G protein-coupled receptor | 0.0 |
41 /
0   |
Muscarinic acetylcholine receptor M4 | CHRM4 | P08173 | CHEMBL1821 | Family A G protein-coupled receptor | 0.0 |
20 /
0   |
Muscarinic acetylcholine receptor M3 | CHRM3 | P20309 | CHEMBL245 | Family A G protein-coupled receptor | 0.0 |
34 /
0   |
Metabotropic glutamate receptor 3 | GRM3 | Q14832 | CHEMBL2888 | Family C G protein-coupled receptor | 0.0 |
2 /
0   |
Kappa Opioid receptor | OPRK1 | P41145 | CHEMBL237 | Family A G protein-coupled receptor | 0.0 |
35 /
16   |
Dipeptidyl peptidase VIII | DPP8 | Q6V1X1 | CHEMBL4657 | Protease | 0.0 |
54 /
0   |
Dipeptidyl peptidase IX | DPP9 | Q86TI2 | CHEMBL4793 | Protease | 0.0 |
44 /
0   |
Neuronal acetylcholine receptor; alpha3/alpha6/beta2/beta3 | CHRNB3 CHRNA6 CHRNB2 CHRNA3 | Q05901 Q15825 P17787 P32297 | CHEMBL2109233 | Ligand-gated ion channel | 0.0 |
4 /
0   |
Adrenergic receptor beta | ADRB2 | P07550 | CHEMBL210 | Family A G protein-coupled receptor | 0.0 |
6 /
0   |
Myeloperoxidase | MPO | P05164 | CHEMBL2439 | Enzyme | 0.0 |
21 /
0   |
Lethal(3)malignant brain tumor-like protein 3 | L3MBTL3 | Q96JM7 | CHEMBL1287623 | Reader | 0.0 |
6 /
0   |
Estrogen receptor beta | ESR2 | Q92731 | CHEMBL242 | Nuclear receptor | 0.0 |
2 /
0   |
Butyrylcholinesterase | BCHE | P06276 | CHEMBL1914 | Hydrolase | 0.0 |
19 /
0   |
Serine/threonine-protein kinase PIM1 | PIM1 | P11309 | CHEMBL2147 | Kinase | 0.0 |
26 /
0   |
Dipeptidyl peptidase II | DPP7 | Q9UHL4 | CHEMBL3976 | Protease | 0.0 |
41 /
0   |
Serotonin 3a (5-HT3a) receptor | HTR3A | P46098 | CHEMBL1899 | Ligand-gated ion channel | 0.0 |
25 /
0   |
Histone acetyltransferase PCAF | KAT2B | Q92831 | CHEMBL5500 | Writer | 0.0 |
6 /
0   |
Carbonic anhydrase II | CA2 | P00918 | CHEMBL205 | Lyase | 0.0 |
35 /
0   |
Myosin light chain kinase, smooth muscle | MYLK | Q15746 | CHEMBL2428 | Kinase | 0.0 |
3 /
0   |
Carbonic anhydrase I | CA1 | P00915 | CHEMBL261 | Lyase | 0.0 |
8 /
0   |
Poly [ADP-ribose] polymerase-1 | PARP1 | P09874 | CHEMBL3105 | Enzyme | 0.0 |
17 /
0   |
Phospholipase D1 | PLD1 | Q13393 | CHEMBL2536 | Hydrolase | 0.0 |
1 /
0   |
Hormone sensitive lipase | LIPE | Q05469 | CHEMBL3590 | Enzyme | 0.0 |
1 /
0   |
MAP kinase p38 alpha | MAPK14 | Q16539 | CHEMBL260 | Kinase | 0.0 |
4 /
0   |
Leukotriene A4 hydrolase | LTA4H | P09960 | CHEMBL4618 | Protease | 0.0 |
7 /
0   |
Histamine H2 receptor | HRH2 | P25021 | CHEMBL1941 | Family A G protein-coupled receptor | 0.0 |
10 /
0   |
Transient receptor potential cation channel subfamily V member 4 | TRPV4 | Q9HBA0 | CHEMBL3119 | Voltage-gated ion channel | 0.0 |
1 /
0   |
PDZ-binding kinase | PBK | Q96KB5 | CHEMBL4896 | Kinase | 0.0 |
1 /
0   |
Melatonin receptor 1A | MTNR1A | P48039 | CHEMBL1945 | Family A G protein-coupled receptor | 0.0 |
0 /
8   |
Fibroblast activation protein alpha | FAP | Q12884 | CHEMBL4683 | Protease | 0.0 |
17 /
0   |
Neuronal acetylcholine receptor subunit alpha-3 | CHRNA3 | P32297 | CHEMBL3068 | Ligand-gated ion channel | 0.0 |
8 /
0   |
Muscarinic acetylcholine receptor M5 | CHRM5 | P08912 | CHEMBL2035 | Family A G protein-coupled receptor | 0.0 |
13 /
0   |
Nitric-oxide synthase, endothelial | NOS3 | P29474 | CHEMBL4803 | Enzyme | 0.0 |
6 /
0   |
Adenosine A3 receptor | ADORA3 | P0DMS8 | CHEMBL256 | Family A G protein-coupled receptor | 0.0 |
1 /
0   |
MBT domain-containing protein 1 | MBTD1 | Q05BQ5 | CHEMBL1287625 | Reader | 0.0 |
1 /
0   |
Carbonic anhydrase XII | CA12 | O43570 | CHEMBL3242 | Lyase | 0.0 |
4 /
0   |
Carbonic anhydrase IX | CA9 | Q16790 | CHEMBL3594 | Lyase | 0.0 |
5 /
0   |
GABA-A receptor; alpha-3/beta-3/gamma-2 | GABRB3 GABRA3 GABRG2 | P28472 P34903 P18507 | CHEMBL2094120 | Ligand-gated ion channel | 0.0 |
2 /
0   |
GABA-A receptor; alpha-1/beta-3/gamma-2 | GABRB3 GABRG2 GABRA1 | P28472 P18507 P14867 | CHEMBL2094121 | Ligand-gated ion channel | 0.0 |
2 /
0   |
GABA-A receptor; alpha-5/beta-3/gamma-2 | GABRB3 GABRG2 GABRA5 | P28472 P18507 P31644 | CHEMBL2094122 | Ligand-gated ion channel | 0.0 |
2 /
0   |
GABA-A receptor; alpha-2/beta-3/gamma-2 | GABRA2 GABRB3 GABRG2 | P47869 P28472 P18507 | CHEMBL2094130 | Ligand-gated ion channel | 0.0 |
2 /
0   |
Gamma-secretase | PSEN2 PSENEN NCSTN APH1A PSEN1 APH1B | P49810 Q9NZ42 Q92542 Q96BI3 P49768 Q8WW43 | CHEMBL2094135 | Protease | 0.0 |
2 /
0   |
Protein tyrosine kinase 2 beta | PTK2B | Q14289 | CHEMBL5469 | Kinase | 0.0 |
2 /
0   |
Nociceptin receptor | OPRL1 | P41146 | CHEMBL2014 | Family A G protein-coupled receptor | 0.0 |
17 /
0   |
Sodium channel protein type IV alpha subunit | SCN4A | P35499 | CHEMBL2072 | Voltage-gated ion channel | 0.0 |
2 /
0   |
Progesterone receptor | PGR | P06401 | CHEMBL208 | Nuclear receptor | 0.0 |
6 /
0   |
Carbonic anhydrase IV | CA4 | P22748 | CHEMBL3729 | Lyase | 0.0 |
2 /
0   |
Serine/threonine-protein kinase AKT2 | AKT2 | P31751 | CHEMBL2431 | Kinase | 0.0 |
21 /
0   |
Multidrug resistance-associated protein 1 | ABCC1 | P33527 | CHEMBL3004 | Primary active transporter | 0.0 |
3 /
0   |
ATP-binding cassette sub-family G member 2 | ABCG2 | Q9UNQ0 | CHEMBL5393 | Primary active transporter | 0.0 |
1 /
0   |
Metastin receptor | KISS1R | Q969F8 | CHEMBL5413 | Family A G protein-coupled receptor | 0.0 |
5 /
0   |
Proteinase activated receptor 4 | F2RL3 | Q96RI0 | CHEMBL4691 | Family A G protein-coupled receptor | 0.0 |
2 /
0   |
Bromodomain adjacent to zinc finger domain protein 2A | BAZ2A | Q9UIF9 | CHEMBL3108642 | Reader | 0.0 |
1 /
0   |
Aminopeptidase A | ENPEP | Q07075 | CHEMBL3439 | Protease | 0.0 |
1 /
0   |
Histamine N-methyltransferase (by homology) | HNMT | P50135 | CHEMBL2190 | Enzyme | 0.0 |
5 /
0   |
Nuclear receptor subfamily 1 group D member 1 | NR1D1 | P20393 | CHEMBL1961783 | Nuclear receptor | 0.0 |
4 /
0   |
Mu opioid receptor | OPRM1 | P35372 | CHEMBL233 | Family A G protein-coupled receptor | 0.0 |
44 /
22   |
Rho-associated protein kinase 1 | ROCK1 | Q13464 | CHEMBL3231 | Kinase | 0.0 |
15 /
0   |
Serine/threonine-protein kinase AKT | AKT1 | P31749 | CHEMBL4282 | Kinase | 0.0 |
13 /
0   |
Beta-1 adrenergic receptor | ADRB1 | P08588 | CHEMBL213 | Family A G protein-coupled receptor | 0.0 |
4 /
0   |
Dopamine D3 receptor | DRD3 | P35462 | CHEMBL234 | Family A G protein-coupled receptor | 0.0 |
152 /
12   |
Heat shock protein 75 kDa, mitochondrial | TRAP1 | Q12931 | CHEMBL1075132 | Other cytosolic protein | 0.0 |
2 /
0   |
Endoplasmin | HSP90B1 | P14625 | CHEMBL1075323 | Other membrane protein | 0.0 |
5 /
0   |
Diamine oxidase | AOC1 | P19801 | CHEMBL2118 | Enzyme | 0.0 |
5 /
0   |
Cathepsin S | CTSS | P25774 | CHEMBL2954 | Protease | 0.0 |
3 /
0   |
Dipeptidyl peptidase I | CTSC | P53634 | CHEMBL2252 | Protease | 0.0 |
11 /
0   |
Glycogen synthase kinase-3 beta | GSK3B | P49841 | CHEMBL262 | Kinase | 0.0 |
5 /
0   |
Rho-associated protein kinase 2 | ROCK2 | O75116 | CHEMBL2973 | Kinase | 0.0 |
17 /
0   |
Choline kinase alpha | CHKA | P35790 | CHEMBL3117 | Enzyme | 0.0 |
1 /
0   |
*Probability for the query molecule - assumed as bioactive - to have this protein as target.